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000259695 1001_ $$00009-0005-3256-2918$$aSinner, Pia$$b0
000259695 245__ $$aMicroglial expression of CD83 governs cellular activation and restrains neuroinflammation in experimental autoimmune encephalomyelitis.
000259695 260__ $$a[London]$$bNature Publishing Group UK$$c2023
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000259695 520__ $$aMicroglial activation during neuroinflammation is crucial for coordinating the immune response against neuronal tissue, and the initial response of microglia determines the severity of neuro-inflammatory diseases. The CD83 molecule has been recently shown to modulate the activation status of dendritic cells and macrophages. Although the expression of CD83 is associated with early microglia activation in various disease settings, its functional relevance for microglial biology has been elusive. Here, we describe a thorough assessment of CD83 regulation in microglia and show that CD83 expression in murine microglia is not only associated with cellular activation but also with pro-resolving functions. Using single-cell RNA-sequencing, we reveal that conditional deletion of CD83 results in an over-activated state during neuroinflammation in the experimental autoimmune encephalomyelitis model. Subsequently, CD83-deficient microglia recruit more pathogenic immune cells to the central nervous system, deteriorating resolving mechanisms and exacerbating the disease. Thus, CD83 in murine microglia orchestrates cellular activation and, consequently, also the resolution of neuroinflammation.
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000259695 650_2 $$2MeSH$$aMice
000259695 650_2 $$2MeSH$$aAnimals
000259695 650_2 $$2MeSH$$aEncephalomyelitis, Autoimmune, Experimental
000259695 650_2 $$2MeSH$$aMicroglia: metabolism
000259695 650_2 $$2MeSH$$aNeuroinflammatory Diseases
000259695 650_2 $$2MeSH$$aCentral Nervous System: metabolism
000259695 650_2 $$2MeSH$$aMacrophages: metabolism
000259695 650_2 $$2MeSH$$aMice, Inbred C57BL
000259695 7001_ $$00000-0001-8258-0691$$aPeckert-Maier, Katrin$$b1
000259695 7001_ $$00000-0003-2565-2702$$aMohammadian, Hashem$$b2
000259695 7001_ $$aKuhnt, Christine$$b3
000259695 7001_ $$aDraßner, Christina$$b4
000259695 7001_ $$0P:(DE-2719)2813672$$aPanagiotakopoulou, Vasiliki$$b5$$udzne
000259695 7001_ $$00000-0001-8306-9334$$aRauber, Simon$$b6
000259695 7001_ $$aLinnerbauer, Mathias$$b7
000259695 7001_ $$aHaimon, Zhana$$b8
000259695 7001_ $$aRoyzman, Dmytro$$b9
000259695 7001_ $$0P:(DE-2719)9001451$$aKronenberg-Versteeg, Deborah$$b10$$udzne
000259695 7001_ $$aRamming, Andreas$$b11
000259695 7001_ $$aSteinkasserer, Alexander$$b12
000259695 7001_ $$00009-0005-6008-2874$$aWild, Andreas B$$b13
000259695 773__ $$0PERI:(DE-600)2553671-0$$a10.1038/s41467-023-40370-2$$gVol. 14, no. 1, p. 4601$$n1$$p4601$$tNature Communications$$v14$$x2041-1723$$y2023
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000259695 9201_ $$0I:(DE-2719)1210011$$kAG Deleidi$$lMitochondria and Inflammation in Neurodegenerative Diseases$$x0
000259695 9201_ $$0I:(DE-2719)1210001$$kAG Jucker$$lCell Biology of Neurological Diseases$$x1
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