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000259697 1001_ $$aChen, Fushun$$b0
000259697 245__ $$asox1a:eGFP transgenic line and single-cell transcriptomics reveal the origin of zebrafish intraspinal serotonergic neurons.
000259697 260__ $$aSt. Louis$$bElsevier$$c2023
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000259697 520__ $$aSox transcription factors are crucial for vertebrate nervous system development. In zebrafish embryo, sox1 genes are expressed in neural progenitor cells and neurons of ventral spinal cord. Our recent study revealed that the loss of sox1a and sox1b function results in a significant decline of V2 subtype neurons (V2s). Using single-cell RNA sequencing, we analyzed the transcriptome of sox1a lineage progenitors and neurons in the zebrafish spinal cord at four time points during embryonic development, employing the Tg(sox1a:eGFP) line. In addition to previously characterized sox1a-expressing neurons, we discovered the expression of sox1a in late-developing intraspinal serotonergic neurons (ISNs). Developmental trajectory analysis suggests that ISNs arise from lateral floor plate (LFP) progenitor cells. Pharmacological inhibition of the Notch signaling pathway revealed its role in negatively regulating LFP progenitor cell differentiation into ISNs. Our findings highlight the zebrafish LFP as a progenitor domain for ISNs, alongside known Kolmer-Agduhr (KA) and V3 interneurons.
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000259697 650_7 $$2Other$$aCell biology
000259697 650_7 $$2Other$$aNeuroscience
000259697 650_7 $$2Other$$aOmics
000259697 650_7 $$2Other$$aTranscriptomics
000259697 7001_ $$aKöhler, Melina$$b1
000259697 7001_ $$aCucun, Gokhan$$b2
000259697 7001_ $$aTakamiya, Masanari$$b3
000259697 7001_ $$0P:(DE-2719)2811030$$aKizil, Caghan$$b4$$udzne
000259697 7001_ $$0P:(DE-2719)2811286$$aCosacak, Mehmet Ilyas$$b5$$udzne
000259697 7001_ $$aRastegar, Sepand$$b6
000259697 773__ $$0PERI:(DE-600)2927064-9$$a10.1016/j.isci.2023.107342$$gVol. 26, no. 8, p. 107342 -$$n8$$p107342$$tiScience$$v26$$x2589-0042$$y2023
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000259697 9201_ $$0I:(DE-2719)1710007$$kAG Kizil$$lMechanisms of Induced Plasticity of the Vertebrate Brain$$x0
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