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@ARTICLE{Chen:259697,
      author       = {Chen, Fushun and Köhler, Melina and Cucun, Gokhan and
                      Takamiya, Masanari and Kizil, Caghan and Cosacak, Mehmet
                      Ilyas and Rastegar, Sepand},
      title        = {sox1a:e{GFP} transgenic line and single-cell
                      transcriptomics reveal the origin of zebrafish intraspinal
                      serotonergic neurons.},
      journal      = {iScience},
      volume       = {26},
      number       = {8},
      issn         = {2589-0042},
      address      = {St. Louis},
      publisher    = {Elsevier},
      reportid     = {DZNE-2023-00769},
      pages        = {107342},
      year         = {2023},
      abstract     = {Sox transcription factors are crucial for vertebrate
                      nervous system development. In zebrafish embryo, sox1 genes
                      are expressed in neural progenitor cells and neurons of
                      ventral spinal cord. Our recent study revealed that the loss
                      of sox1a and sox1b function results in a significant decline
                      of V2 subtype neurons (V2s). Using single-cell RNA
                      sequencing, we analyzed the transcriptome of sox1a lineage
                      progenitors and neurons in the zebrafish spinal cord at four
                      time points during embryonic development, employing the
                      Tg(sox1a:eGFP) line. In addition to previously characterized
                      sox1a-expressing neurons, we discovered the expression of
                      sox1a in late-developing intraspinal serotonergic neurons
                      (ISNs). Developmental trajectory analysis suggests that ISNs
                      arise from lateral floor plate (LFP) progenitor cells.
                      Pharmacological inhibition of the Notch signaling pathway
                      revealed its role in negatively regulating LFP progenitor
                      cell differentiation into ISNs. Our findings highlight the
                      zebrafish LFP as a progenitor domain for ISNs, alongside
                      known Kolmer-Agduhr (KA) and V3 interneurons.},
      keywords     = {Cell biology (Other) / Neuroscience (Other) / Omics (Other)
                      / Transcriptomics (Other)},
      cin          = {AG Kizil},
      ddc          = {050},
      cid          = {I:(DE-2719)1710007},
      pnm          = {352 - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37529101},
      pmc          = {pmc:PMC10387610},
      doi          = {10.1016/j.isci.2023.107342},
      url          = {https://pub.dzne.de/record/259697},
}