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000259704 1001_ $$00000-0003-4123-2548$$aMcKay, Nicole S$$b0
000259704 245__ $$aPositron emission tomography and magnetic resonance imaging methods and datasets within the Dominantly Inherited Alzheimer Network (DIAN).
000259704 260__ $$aNew York, NY$$bNature America$$c2023
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000259704 520__ $$aThe Dominantly Inherited Alzheimer Network (DIAN) is an international collaboration studying autosomal dominant Alzheimer disease (ADAD). ADAD arises from mutations occurring in three genes. Offspring from ADAD families have a 50% chance of inheriting their familial mutation, so non-carrier siblings can be recruited for comparisons in case-control studies. The age of onset in ADAD is highly predictable within families, allowing researchers to estimate an individual's point in the disease trajectory. These characteristics allow candidate AD biomarker measurements to be reliably mapped during the preclinical phase. Although ADAD represents a small proportion of AD cases, understanding neuroimaging-based changes that occur during the preclinical period may provide insight into early disease stages of 'sporadic' AD also. Additionally, this study provides rich data for research in healthy aging through inclusion of the non-carrier controls. Here we introduce the neuroimaging dataset collected and describe how this resource can be used by a range of researchers.
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000259704 650_7 $$2NLM Chemicals$$aAmyloid beta-Peptides
000259704 650_2 $$2MeSH$$aHumans
000259704 650_2 $$2MeSH$$aAlzheimer Disease: diagnostic imaging
000259704 650_2 $$2MeSH$$aAlzheimer Disease: genetics
000259704 650_2 $$2MeSH$$aPositron-Emission Tomography
000259704 650_2 $$2MeSH$$aMagnetic Resonance Imaging
000259704 650_2 $$2MeSH$$aNeuroimaging
000259704 650_2 $$2MeSH$$aArthrogryposis
000259704 650_2 $$2MeSH$$aMutation: genetics
000259704 650_2 $$2MeSH$$aAmyloid beta-Peptides: genetics
000259704 693__ $$0EXP:(DE-2719)DIAN-20090101$$5EXP:(DE-2719)DIAN-20090101$$eLongitudinal Study on Dominantly Inherited Alzheimer's Disease$$x0
000259704 7001_ $$00000-0003-2109-2955$$aGordon, Brian A$$b1
000259704 7001_ $$aHornbeck, Russ C$$b2
000259704 7001_ $$aDincer, Aylin$$b3
000259704 7001_ $$00000-0003-2726-8704$$aFlores, Shaney$$b4
000259704 7001_ $$aKeefe, Sarah J$$b5
000259704 7001_ $$00000-0002-9735-5152$$aJoseph-Mathurin, Nelly$$b6
000259704 7001_ $$00000-0001-7916-622X$$aJack, Clifford R$$b7
000259704 7001_ $$aKoeppe, Robert$$b8
000259704 7001_ $$00000-0003-4588-739X$$aMillar, Peter R$$b9
000259704 7001_ $$aAnces, Beau M$$b10
000259704 7001_ $$00000-0001-6698-1268$$aChen, Charles D$$b11
000259704 7001_ $$aDaniels, Alisha$$b12
000259704 7001_ $$00000-0001-7822-6411$$aHobbs, Diana A$$b13
000259704 7001_ $$aJackson, Kelley$$b14
000259704 7001_ $$aKoudelis, Deborah$$b15
000259704 7001_ $$aMassoumzadeh, Parinaz$$b16
000259704 7001_ $$aMcCullough, Austin$$b17
000259704 7001_ $$aNickels, Michael L$$b18
000259704 7001_ $$aRahmani, Farzaneh$$b19
000259704 7001_ $$aSwisher, Laura$$b20
000259704 7001_ $$0P:(DE-HGF)0$$aWang, Qing$$b21
000259704 7001_ $$00000-0001-7166-1234$$aAllegri, Ricardo F$$b22
000259704 7001_ $$aBerman, Sarah B$$b23
000259704 7001_ $$aBrickman, Adam M$$b24
000259704 7001_ $$00000-0001-8603-4233$$aBrooks, William S$$b25
000259704 7001_ $$00000-0001-7833-616X$$aCash, David M$$b26
000259704 7001_ $$00000-0002-7792-1698$$aChhatwal, Jasmeer P$$b27
000259704 7001_ $$00000-0001-5133-5538$$aDay, Gregory S$$b28
000259704 7001_ $$aFarlow, Martin R$$b29
000259704 7001_ $$0P:(DE-2719)9000177$$ala Fougère, Christian$$b30
000259704 7001_ $$aFox, Nick C$$b31
000259704 7001_ $$00000-0003-0602-6319$$aFulham, Michael$$b32
000259704 7001_ $$00000-0002-1842-8019$$aGhetti, Bernardino$$b33
000259704 7001_ $$aGraff-Radford, Neill$$b34
000259704 7001_ $$00000-0001-8828-8085$$aIkeuchi, Takeshi$$b35
000259704 7001_ $$aKlunk, William$$b36
000259704 7001_ $$0P:(DE-HGF)0$$aLee, Jae-Hong$$b37
000259704 7001_ $$0P:(DE-2719)2811659$$aLevin, Johannes$$b38$$udzne
000259704 7001_ $$aMartins, Ralph$$b39
000259704 7001_ $$aMasters, Colin L$$b40
000259704 7001_ $$aMcConathy, Jonathan$$b41
000259704 7001_ $$aMori, Hiroshi$$b42
000259704 7001_ $$aNoble, James M$$b43
000259704 7001_ $$aReischl, Gerald$$b44
000259704 7001_ $$aRowe, Christopher$$b45
000259704 7001_ $$00000-0002-2631-0942$$aSalloway, Stephen$$b46
000259704 7001_ $$aSanchez-Valle, Raquel$$b47
000259704 7001_ $$00000-0003-2967-9662$$aSchofield, Peter R$$b48
000259704 7001_ $$aShimada, Hiroyuki$$b49
000259704 7001_ $$aShoji, Mikio$$b50
000259704 7001_ $$00000-0002-1946-8063$$aSu, Yi$$b51
000259704 7001_ $$aSuzuki, Kazushi$$b52
000259704 7001_ $$0P:(DE-2719)2811820$$aVöglein, Jonathan$$b53$$udzne
000259704 7001_ $$aYakushev, Igor$$b54
000259704 7001_ $$00000-0002-0276-2899$$aCruchaga, Carlos$$b55
000259704 7001_ $$aHassenstab, Jason$$b56
000259704 7001_ $$00000-0002-6854-5547$$aKarch, Celeste$$b57
000259704 7001_ $$00000-0002-6764-3866$$aMcDade, Eric$$b58
000259704 7001_ $$00000-0002-3443-7716$$aPerrin, Richard J$$b59
000259704 7001_ $$aXiong, Chengjie$$b60
000259704 7001_ $$aMorris, John C$$b61
000259704 7001_ $$00000-0002-7729-1702$$aBateman, Randall J$$b62
000259704 7001_ $$00000-0002-8114-0552$$aBenzinger, Tammie L S$$b63
000259704 7001_ $$aNetwork, Dominantly Inherited Alzheimer$$b64$$eCollaboration Author
000259704 7001_ $$aBrickman, Adam M$$b65$$eContributor
000259704 7001_ $$ala Fougère, Christian$$b66$$eContributor
000259704 773__ $$0PERI:(DE-600)1494955-6$$a10.1038/s41593-023-01359-8$$gVol. 26, no. 8, p. 1449 - 1460$$n8$$p1449 - 1460$$tNature neuroscience$$v26$$x1097-6256$$y2023
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