Home > Publications Database > Positron emission tomography and magnetic resonance imaging methods and datasets within the Dominantly Inherited Alzheimer Network (DIAN). > print

001     259704
005     20231004134657.0
024 7 _ |a 10.1038/s41593-023-01359-8
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024 7 _ |a pmid:37429916
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024 7 _ |a pmc:PMC10400428
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024 7 _ |a 1097-6256
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024 7 _ |a 1546-1726
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024 7 _ |a altmetric:151196086
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037 _ _ |a DZNE-2023-00776
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a McKay, Nicole S
|0 0000-0003-4123-2548
|b 0
245 _ _ |a Positron emission tomography and magnetic resonance imaging methods and datasets within the Dominantly Inherited Alzheimer Network (DIAN).
260 _ _ |a New York, NY
|c 2023
|b Nature America
336 7 _ |a article
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336 7 _ |a ARTICLE
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520 _ _ |a The Dominantly Inherited Alzheimer Network (DIAN) is an international collaboration studying autosomal dominant Alzheimer disease (ADAD). ADAD arises from mutations occurring in three genes. Offspring from ADAD families have a 50% chance of inheriting their familial mutation, so non-carrier siblings can be recruited for comparisons in case-control studies. The age of onset in ADAD is highly predictable within families, allowing researchers to estimate an individual's point in the disease trajectory. These characteristics allow candidate AD biomarker measurements to be reliably mapped during the preclinical phase. Although ADAD represents a small proportion of AD cases, understanding neuroimaging-based changes that occur during the preclinical period may provide insight into early disease stages of 'sporadic' AD also. Additionally, this study provides rich data for research in healthy aging through inclusion of the non-carrier controls. Here we introduce the neuroimaging dataset collected and describe how this resource can be used by a range of researchers.
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650 _ 7 |a Amyloid beta-Peptides
|2 NLM Chemicals
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Alzheimer Disease: diagnostic imaging
|2 MeSH
650 _ 2 |a Alzheimer Disease: genetics
|2 MeSH
650 _ 2 |a Positron-Emission Tomography
|2 MeSH
650 _ 2 |a Magnetic Resonance Imaging
|2 MeSH
650 _ 2 |a Neuroimaging
|2 MeSH
650 _ 2 |a Arthrogryposis
|2 MeSH
650 _ 2 |a Mutation: genetics
|2 MeSH
650 _ 2 |a Amyloid beta-Peptides: genetics
|2 MeSH
693 _ _ |0 EXP:(DE-2719)DIAN-20090101
|5 EXP:(DE-2719)DIAN-20090101
|e Longitudinal Study on Dominantly Inherited Alzheimer's Disease
|x 0
700 1 _ |a Gordon, Brian A
|0 0000-0003-2109-2955
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700 1 _ |a Hornbeck, Russ C
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700 1 _ |a Dincer, Aylin
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700 1 _ |a Flores, Shaney
|0 0000-0003-2726-8704
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700 1 _ |a Keefe, Sarah J
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700 1 _ |a Joseph-Mathurin, Nelly
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700 1 _ |a Jack, Clifford R
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700 1 _ |a Koeppe, Robert
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700 1 _ |a Millar, Peter R
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700 1 _ |a Ances, Beau M
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700 1 _ |a Chen, Charles D
|0 0000-0001-6698-1268
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700 1 _ |a Daniels, Alisha
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700 1 _ |a Hobbs, Diana A
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700 1 _ |a Jackson, Kelley
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700 1 _ |a Koudelis, Deborah
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700 1 _ |a Massoumzadeh, Parinaz
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700 1 _ |a McCullough, Austin
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700 1 _ |a Nickels, Michael L
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700 1 _ |a Rahmani, Farzaneh
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700 1 _ |a Swisher, Laura
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700 1 _ |a Wang, Qing
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700 1 _ |a Allegri, Ricardo F
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700 1 _ |a Berman, Sarah B
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700 1 _ |a Brickman, Adam M
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700 1 _ |a Brooks, William S
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700 1 _ |a Cash, David M
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700 1 _ |a Chhatwal, Jasmeer P
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700 1 _ |a Day, Gregory S
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700 1 _ |a Farlow, Martin R
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700 1 _ |a la Fougère, Christian
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700 1 _ |a Fox, Nick C
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700 1 _ |a Fulham, Michael
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700 1 _ |a Ghetti, Bernardino
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700 1 _ |a Graff-Radford, Neill
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700 1 _ |a Ikeuchi, Takeshi
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700 1 _ |a Klunk, William
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700 1 _ |a Lee, Jae-Hong
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700 1 _ |a Levin, Johannes
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700 1 _ |a Martins, Ralph
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700 1 _ |a Masters, Colin L
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700 1 _ |a McConathy, Jonathan
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700 1 _ |a Mori, Hiroshi
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700 1 _ |a Noble, James M
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700 1 _ |a Reischl, Gerald
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700 1 _ |a Rowe, Christopher
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700 1 _ |a Salloway, Stephen
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700 1 _ |a Sanchez-Valle, Raquel
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700 1 _ |a Schofield, Peter R
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700 1 _ |a Shimada, Hiroyuki
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700 1 _ |a Shoji, Mikio
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700 1 _ |a Su, Yi
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700 1 _ |a Suzuki, Kazushi
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700 1 _ |a Vöglein, Jonathan
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700 1 _ |a Yakushev, Igor
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700 1 _ |a Cruchaga, Carlos
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700 1 _ |a Hassenstab, Jason
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700 1 _ |a Karch, Celeste
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700 1 _ |a McDade, Eric
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700 1 _ |a Perrin, Richard J
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700 1 _ |a Xiong, Chengjie
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700 1 _ |a Morris, John C
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700 1 _ |a Bateman, Randall J
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700 1 _ |a Benzinger, Tammie L S
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700 1 _ |a Network, Dominantly Inherited Alzheimer
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700 1 _ |a Brickman, Adam M
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700 1 _ |a la Fougère, Christian
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773 _ _ |a 10.1038/s41593-023-01359-8
|g Vol. 26, no. 8, p. 1449 - 1460
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|t Nature neuroscience
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