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000259707 1001_ $$0P:(DE-2719)9001743$$aFriedrich, Krohn$$b0$$eFirst author$$udzne
000259707 245__ $$aNoradrenergic neuromodulation in ageing and disease.
000259707 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2023
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000259707 520__ $$aThe locus coeruleus (LC) is a small brainstem structure located in the lower pons and is the main source of noradrenaline (NA) in the brain. Via its phasic and tonic firing, it modulates cognition and autonomic functions and is involved in the brain's immune response. The extent of degeneration to the LC in healthy ageing remains unclear, however, noradrenergic dysfunction may contribute to the pathogenesis of Alzheimer's (AD) and Parkinson's disease (PD). Despite their differences in progression at later disease stages, the early involvement of the LC may lead to comparable behavioural symptoms such as preclinical sleep problems and neuropsychiatric symptoms as a result of AD and PD pathology. In this review, we draw attention to the mechanisms that underlie LC degeneration in ageing, AD and PD. We aim to motivate future research to investigate how early degeneration of the noradrenergic system may play a pivotal role in the pathogenesis of AD and PD which may also be relevant to other neurodegenerative diseases.
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000259707 650_7 $$2Other$$aLocus coeruleus
000259707 650_7 $$2Other$$aNoradrenaline
000259707 650_7 $$2Other$$aNoradrenergic neuromodulation
000259707 650_7 $$0X4W3ENH1CV$$2NLM Chemicals$$aNorepinephrine
000259707 650_2 $$2MeSH$$aHumans
000259707 650_2 $$2MeSH$$aLocus Coeruleus: physiology
000259707 650_2 $$2MeSH$$aBrain: pathology
000259707 650_2 $$2MeSH$$aBrain Stem: pathology
000259707 650_2 $$2MeSH$$aParkinson Disease: pathology
000259707 650_2 $$2MeSH$$aNorepinephrine
000259707 650_2 $$2MeSH$$aAlzheimer Disease: pathology
000259707 7001_ $$0P:(DE-2719)9002565$$aLancini, E.$$b1
000259707 7001_ $$0P:(DE-HGF)0$$aLudwig, M.$$b2
000259707 7001_ $$0P:(DE-2719)9001927$$aLeiman, M.$$b3
000259707 7001_ $$0P:(DE-2719)9002076$$aGurusamy, Guruprasath$$b4$$udzne
000259707 7001_ $$0P:(DE-HGF)0$$aHaag, L.$$b5
000259707 7001_ $$0P:(DE-HGF)0$$aPanczyszyn, J.$$b6
000259707 7001_ $$0P:(DE-2719)2000005$$aDüzel, E.$$b7
000259707 7001_ $$0P:(DE-2719)2811927$$aHämmerer, D.$$b8
000259707 7001_ $$0P:(DE-2719)2810555$$aBetts, Matthew$$b9$$eLast author
000259707 773__ $$0PERI:(DE-600)1498433-7$$a10.1016/j.neubiorev.2023.105311$$gVol. 152, p. 105311 -$$p105311$$tNeuroscience & biobehavioral reviews$$v152$$x0149-7634$$y2023
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