TY  - JOUR
AU  - Emery, Brett Addison
AU  - Hu, Xin
AU  - Khanzada, Shahrukh
AU  - Kempermann, Gerd
AU  - Amin, Hayder
TI  - High-resolution CMOS-based biosensor for assessing hippocampal circuit dynamics in experience-dependent plasticity.
JO  - Biosensors and bioelectronics
VL  - 237
SN  - 0956-5663
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - DZNE-2023-00797
SP  - 115471
PY  - 2023
AB  - Experiential richness creates tissue-level changes and synaptic plasticity as patterns emerge from rhythmic spatiotemporal activity of large interconnected neuronal assemblies. Despite numerous experimental and computational approaches at different scales, the precise impact of experience on network-wide computational dynamics remains inaccessible due to the lack of applicable large-scale recording methodology. We here demonstrate a large-scale multi-site biohybrid brain circuity on-CMOS-based biosensor with an unprecedented spatiotemporal resolution of 4096 microelectrodes, which allows simultaneous electrophysiological assessment across the entire hippocampal-cortical subnetworks from mice living in an enriched environment (ENR) and standard-housed (SD) conditions. Our platform, empowered with various computational analyses, reveals environmental enrichment's impacts on local and global spatiotemporal neural dynamics, firing synchrony, topological network complexity, and large-scale connectome. Our results delineate the distinct role of prior experience in enhancing multiplexed dimensional coding formed by neuronal ensembles and error tolerance and resilience to random failures compared to standard conditions. The scope and depth of these effects highlight the critical role of high-density, large-scale biosensors to provide a new understanding of the computational dynamics and information processing in multimodal physiological and experience-dependent plasticity conditions and their role in higher brain functions. Knowledge of these large-scale dynamics can inspire the development of biologically plausible computational models and computational artificial intelligence networks and expand the reach of neuromorphic brain-inspired computing into new applications.
KW  - Mice
KW  - Animals
KW  - Artificial Intelligence
KW  - Biosensing Techniques
KW  - Neurons: physiology
KW  - Hippocampus
KW  - Cerebral Cortex
KW  - CMOS-MEAs (Other)
KW  - Connectome (Other)
KW  - Enriched environment (Other)
KW  - Graph theory (Other)
KW  - Large-scale biosensors (Other)
KW  - Neural circuit (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:37379793
DO  - DOI:10.1016/j.bios.2023.115471
UR  - https://pub.dzne.de/record/259763
ER  -