000259941 001__ 259941
000259941 005__ 20240112171420.0
000259941 0247_ $$2doi$$a10.1038/s41591-023-02476-4
000259941 0247_ $$2pmid$$apmid:37550416
000259941 0247_ $$2pmc$$apmc:PMC10427428
000259941 0247_ $$2ISSN$$a1078-8956
000259941 0247_ $$2ISSN$$a1546-170X
000259941 0247_ $$2altmetric$$aaltmetric:152630846
000259941 037__ $$aDZNE-2023-00805
000259941 041__ $$aEnglish
000259941 082__ $$a610
000259941 1001_ $$00000-0002-0604-2944$$aJohnson, Erik C B$$b0
000259941 245__ $$aCerebrospinal fluid proteomics define the natural history of autosomal dominant Alzheimer's disease.
000259941 260__ $$aNew York, NY$$bNature America Inc.$$c2023
000259941 3367_ $$2DRIVER$$aarticle
000259941 3367_ $$2DataCite$$aOutput Types/Journal article
000259941 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1694697251_30856
000259941 3367_ $$2BibTeX$$aARTICLE
000259941 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000259941 3367_ $$00$$2EndNote$$aJournal Article
000259941 520__ $$aAlzheimer's disease (AD) pathology develops many years before the onset of cognitive symptoms. Two pathological processes-aggregation of the amyloid-β (Aβ) peptide into plaques and the microtubule protein tau into neurofibrillary tangles (NFTs)-are hallmarks of the disease. However, other pathological brain processes are thought to be key disease mediators of Aβ plaque and NFT pathology. How these additional pathologies evolve over the course of the disease is currently unknown. Here we show that proteomic measurements in autosomal dominant AD cerebrospinal fluid (CSF) linked to brain protein coexpression can be used to characterize the evolution of AD pathology over a timescale spanning six decades. SMOC1 and SPON1 proteins associated with Aβ plaques were elevated in AD CSF nearly 30 years before the onset of symptoms, followed by changes in synaptic proteins, metabolic proteins, axonal proteins, inflammatory proteins and finally decreases in neurosecretory proteins. The proteome discriminated mutation carriers from noncarriers before symptom onset as well or better than Aβ and tau measures. Our results highlight the multifaceted landscape of AD pathophysiology and its temporal evolution. Such knowledge will be critical for developing precision therapeutic interventions and biomarkers for AD beyond those associated with Aβ and tau.
000259941 536__ $$0G:(DE-HGF)POF4-352$$a352 - Disease Mechanisms (POF4-352)$$cPOF4-352$$fPOF IV$$x0
000259941 588__ $$aDataset connected to CrossRef, PubMed, , Journals: pub.dzne.de
000259941 650_2 $$2MeSH$$aAlzheimer Disease: cerebrospinal fluid
000259941 650_2 $$2MeSH$$aHumans
000259941 650_2 $$2MeSH$$aAlzheimer Disease: pathology
000259941 650_2 $$2MeSH$$aProteomics
000259941 650_2 $$2MeSH$$aAmyloid beta-Peptides: metabolism
000259941 650_2 $$2MeSH$$atau Proteins: metabolism
000259941 650_2 $$2MeSH$$aNeurofibrillary Tangles: pathology
000259941 650_2 $$2MeSH$$aBiomarkers: metabolism
000259941 650_2 $$2MeSH$$aAlzheimer Disease: genetics
000259941 650_2 $$2MeSH$$aAlzheimer Disease: physiopathology
000259941 650_2 $$2MeSH$$aMale
000259941 650_2 $$2MeSH$$aFemale
000259941 650_2 $$2MeSH$$aAdult
000259941 650_2 $$2MeSH$$aMiddle Aged
000259941 650_2 $$2MeSH$$aMutation
000259941 650_2 $$2MeSH$$aAge of Onset
000259941 650_7 $$2NLM Chemicals$$aSMOC1 protein, human
000259941 650_7 $$2NLM Chemicals$$aAmyloid beta-Peptides
000259941 650_7 $$2NLM Chemicals$$atau Proteins
000259941 650_7 $$2NLM Chemicals$$aBiomarkers
000259941 693__ $$0EXP:(DE-2719)DIAN-20090101$$5EXP:(DE-2719)DIAN-20090101$$eLongitudinal Study on Dominantly Inherited Alzheimer's Disease$$x0
000259941 7001_ $$aBian, Shijia$$b1
000259941 7001_ $$aHaque, Rafi U$$b2
000259941 7001_ $$00000-0002-5083-0614$$aCarter, E Kathleen$$b3
000259941 7001_ $$00000-0001-6574-0833$$aWatson, Caroline M$$b4
000259941 7001_ $$00000-0003-2109-2955$$aGordon, Brian A$$b5
000259941 7001_ $$aPing, Lingyan$$b6
000259941 7001_ $$aDuong, Duc M$$b7
000259941 7001_ $$00000-0001-9647-9738$$aEpstein, Michael P$$b8
000259941 7001_ $$00000-0002-6764-3866$$aMcDade, Eric$$b9
000259941 7001_ $$aBarthélemy, Nicolas R$$b10
000259941 7001_ $$00000-0002-6854-5547$$aKarch, Celeste M$$b11
000259941 7001_ $$aXiong, Chengjie$$b12
000259941 7001_ $$00000-0002-0276-2899$$aCruchaga, Carlos$$b13
000259941 7001_ $$00000-0002-3443-7716$$aPerrin, Richard J$$b14
000259941 7001_ $$00000-0002-6360-6726$$aWingo, Aliza P$$b15
000259941 7001_ $$00000-0002-7679-6282$$aWingo, Thomas S$$b16
000259941 7001_ $$00000-0002-7792-1698$$aChhatwal, Jasmeer P$$b17
000259941 7001_ $$00000-0001-5133-5538$$aDay, Gregory S$$b18
000259941 7001_ $$aNoble, James M$$b19
000259941 7001_ $$aBerman, Sarah B$$b20
000259941 7001_ $$aMartins, Ralph$$b21
000259941 7001_ $$aGraff-Radford, Neill R$$b22
000259941 7001_ $$00000-0003-2967-9662$$aSchofield, Peter R$$b23
000259941 7001_ $$00000-0001-8828-8085$$aIkeuchi, Takeshi$$b24
000259941 7001_ $$aMori, Hiroshi$$b25
000259941 7001_ $$0P:(DE-2719)2811659$$aLevin, Johannes$$b26$$udzne
000259941 7001_ $$00000-0001-7897-5471$$aFarlow, Martin$$b27
000259941 7001_ $$00000-0002-8810-620X$$aLah, James J$$b28
000259941 7001_ $$0P:(DE-2719)2202037$$aHaass, Christian$$b29
000259941 7001_ $$0P:(DE-2719)2000010$$aJucker, Mathias$$b30
000259941 7001_ $$aMorris, John C$$b31
000259941 7001_ $$00000-0002-8114-0552$$aBenzinger, Tammie L S$$b32
000259941 7001_ $$00000-0001-5466-0053$$aRoberts, Blaine R$$b33
000259941 7001_ $$00000-0002-7729-1702$$aBateman, Randall J$$b34
000259941 7001_ $$aFagan, Anne M$$b35
000259941 7001_ $$00000-0002-4507-624X$$aSeyfried, Nicholas T$$b36
000259941 7001_ $$00000-0002-3153-502X$$aLevey, Allan I$$b37
000259941 7001_ $$aNetwork, Dominantly Inherited Alzheimer$$b38$$eCollaboration Author
000259941 7001_ $$aNoble, James M$$b39$$eContributor
000259941 7001_ $$aDay, Gregory S$$b40$$eContributor
000259941 7001_ $$aGraff-Radford, Neill R$$b41$$eContributor
000259941 7001_ $$aVoglein, Jonathan$$b42$$eContributor
000259941 7001_ $$aAllegri, Ricardo$$b43$$eContributor
000259941 7001_ $$aMendez, Patricio Chrem$$b44$$eContributor
000259941 7001_ $$aSurace, Ezequiel$$b45$$eContributor
000259941 7001_ $$aBerman, Sarah B$$b46$$eContributor
000259941 7001_ $$aIkonomovic, Snezana$$b47$$eContributor
000259941 7001_ $$aNadkarni, Neelesh$$b48$$eContributor
000259941 7001_ $$aLopera, Francisco$$b49$$eContributor
000259941 7001_ $$aRamirez, Laura$$b50$$eContributor
000259941 7001_ $$aAguillon, David$$b51$$eContributor
000259941 7001_ $$aLeon, Yudy$$b52$$eContributor
000259941 7001_ $$aRamos, Claudia$$b53$$eContributor
000259941 7001_ $$aAlzate, Diana$$b54$$eContributor
000259941 7001_ $$aBaena, Ana$$b55$$eContributor
000259941 7001_ $$aLondono, Natalia$$b56$$eContributor
000259941 7001_ $$aMoreno, Sonia$$b57$$eContributor
000259941 7001_ $$aLaske, Christoph$$b58$$eContributor
000259941 7001_ $$aKuder-Buletta, Elke$$b59$$eContributor
000259941 7001_ $$aGraber-Sultan, Susanne$$b60$$eContributor
000259941 7001_ $$aPreische, Oliver$$b61$$eContributor
000259941 7001_ $$aHofmann, Anna$$b62$$eContributor
000259941 7001_ $$aIkeuchi, Takeshi$$b63$$eContributor
000259941 7001_ $$aKasuga, Kensaku$$b64$$eContributor
000259941 7001_ $$aNiimi, Yoshiki$$b65$$eContributor
000259941 7001_ $$aIshii, Kenji$$b66$$eContributor
000259941 7001_ $$aSenda, Michio$$b67$$eContributor
000259941 7001_ $$aSanchez-Valle, Raquel$$b68$$eContributor
000259941 7001_ $$aRosa-Neto, Pedro$$b69$$eContributor
000259941 7001_ $$aFox, Nick$$b70$$eContributor
000259941 7001_ $$aCash, Dave$$b71$$eContributor
000259941 7001_ $$aLee, Jae-Hong$$b72$$eContributor
000259941 7001_ $$aRoh, Jee Hoon$$b73$$eContributor
000259941 7001_ $$aRiddle, Meghan$$b74$$eContributor
000259941 7001_ $$aMenard, William$$b75$$eContributor
000259941 7001_ $$aBodge, Courtney$$b76$$eContributor
000259941 7001_ $$aSurti, Mustafa$$b77$$eContributor
000259941 7001_ $$aTakada, Leonel Tadao$$b78$$eContributor
000259941 7001_ $$aChhatwal, Jasmeer P$$b79$$eContributor
000259941 7001_ $$aSanchez-Gonzalez, V. J.$$b80$$eContributor
000259941 7001_ $$aOrozco-Barajas, Maribel$$b81$$eContributor
000259941 7001_ $$aGoate, Alison$$b82$$eContributor
000259941 7001_ $$aRenton, Alan$$b83$$eContributor
000259941 7001_ $$aEsposito, Bianca$$b84$$eContributor
000259941 7001_ $$aKarch, Celeste M$$b85$$eContributor
000259941 7001_ $$aMarsh, Jacob$$b86$$eContributor
000259941 7001_ $$aCruchaga, Carlos$$b87$$eContributor
000259941 7001_ $$aFernandez, Victoria$$b88$$eContributor
000259941 7001_ $$aGordon, Brian A$$b89$$eContributor
000259941 7001_ $$aFagan, Anne M$$b90$$eContributor
000259941 7001_ $$aJerome, Gina$$b91$$eContributor
000259941 7001_ $$aHerries, Elizabeth$$b92$$eContributor
000259941 7001_ $$aLlibre-Guerra, Jorge$$b93$$eContributor
000259941 7001_ $$aJohnson, Erik C B$$b94$$eContributor
000259941 7001_ $$aSeyfried, Nicholas T$$b95$$eContributor
000259941 7001_ $$aSchofield, Peter R$$b96$$eContributor
000259941 7001_ $$aBrooks, William$$b97$$eContributor
000259941 7001_ $$aBechara, Jacob$$b98$$eContributor
000259941 7001_ $$aBateman, Randall J$$b99$$eContributor
000259941 7001_ $$aHassenstab, Jason$$b100$$eContributor
000259941 7001_ $$aPerrin, Richard J$$b101$$eContributor
000259941 7001_ $$aFranklin, Erin$$b102$$eContributor
000259941 7001_ $$aBenzinger, Tammie L S$$b103$$eContributor
000259941 7001_ $$aChen, Allison$$b104$$eContributor
000259941 7001_ $$aChen, Charles$$b105$$eContributor
000259941 7001_ $$aFlores, Shaney$$b106$$eContributor
000259941 7001_ $$aFriedrichsen, Nelly$$b107$$eContributor
000259941 7001_ $$aHantler, Nancy$$b108$$eContributor
000259941 7001_ $$aHornbeck, Russ$$b109$$eContributor
000259941 7001_ $$aJarman, Steve$$b110$$eContributor
000259941 7001_ $$aKeefe, Sarah$$b111$$eContributor
000259941 7001_ $$aKoudelis, Deborah$$b112$$eContributor
000259941 7001_ $$aMassoumzadeh, Parinaz$$b113$$eContributor
000259941 7001_ $$aMcCullough, Austin$$b114$$eContributor
000259941 7001_ $$aMcKay, Nicole$$b115$$eContributor
000259941 7001_ $$aNicklaus, Joyce$$b116$$eContributor
000259941 7001_ $$aPulizos, Christine$$b117$$eContributor
000259941 7001_ $$aWang, Qing$$b118$$eContributor
000259941 7001_ $$aMishall, Sheetal$$b119$$eContributor
000259941 7001_ $$aSabaredzovic, Edita$$b120$$eContributor
000259941 7001_ $$aDeng, Emily$$b121$$eContributor
000259941 7001_ $$aCandela, Madison$$b122$$eContributor
000259941 7001_ $$aSmith, Hunter$$b123$$eContributor
000259941 7001_ $$aHobbs, Diana$$b124$$eContributor
000259941 7001_ $$aScott, Jalen$$b125$$eContributor
000259941 7001_ $$aLevin, Johannes$$b126$$eContributor
000259941 7001_ $$aXiong, Chengjie$$b127$$eContributor
000259941 7001_ $$aWang, Peter$$b128$$eContributor
000259941 7001_ $$aXu, Xiong$$b129$$eContributor
000259941 7001_ $$aLi, Yan$$b130$$eContributor
000259941 7001_ $$aGremminger, Emily$$b131$$eContributor
000259941 7001_ $$aMa, Yinjiao$$b132$$eContributor
000259941 7001_ $$aBui, Ryan$$b133$$eContributor
000259941 7001_ $$aLu, Ruijin$$b134$$eContributor
000259941 7001_ $$aOrtiz, Ana Luisa Sosa$$b135$$eContributor
000259941 7001_ $$aDaniels, Alisha$$b136$$eContributor
000259941 7001_ $$aCourtney, Laura$$b137$$eContributor
000259941 7001_ $$aSupnet-Bell, Charlene$$b138$$eContributor
000259941 7001_ $$aXu, Jinbin$$b139$$eContributor
000259941 7001_ $$aRingman, John$$b140$$eContributor
000259941 773__ $$0PERI:(DE-600)1484517-9$$a10.1038/s41591-023-02476-4$$gVol. 29, no. 8, p. 1979 - 1988$$n8$$p1979 - 1988$$tNature medicine$$v29$$x1078-8956$$y2023
000259941 8564_ $$uhttps://pub.dzne.de/record/259941/files/DZNE-2023-00805.pdf$$yOpenAccess
000259941 8564_ $$uhttps://pub.dzne.de/record/259941/files/DZNE-2023-00805.pdf?subformat=pdfa$$xpdfa$$yOpenAccess
000259941 909CO $$ooai:pub.dzne.de:259941$$pdnbdelivery$$pdriver$$pVDB$$popen_access$$popenaire
000259941 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)2811659$$aExternal Institute$$b26$$kExtern
000259941 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2202037$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b29$$kDZNE
000259941 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2000010$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b30$$kDZNE
000259941 9131_ $$0G:(DE-HGF)POF4-352$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vDisease Mechanisms$$x0
000259941 9141_ $$y2023
000259941 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000259941 915__ $$0LIC:(DE-HGF)CCBY4$$2HGFVOC$$aCreative Commons Attribution CC BY 4.0
000259941 915__ $$0StatID:(DE-HGF)0420$$2StatID$$aNationallizenz$$d2023-08-29$$wger
000259941 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2023-08-29
000259941 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2023-08-29
000259941 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2023-08-29
000259941 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2023-08-29
000259941 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2023-08-29
000259941 915__ $$0StatID:(DE-HGF)1110$$2StatID$$aDBCoverage$$bCurrent Contents - Clinical Medicine$$d2023-08-29
000259941 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bNAT MED : 2022$$d2023-08-29
000259941 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2023-08-29
000259941 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2023-08-29
000259941 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2023-08-29
000259941 915__ $$0StatID:(DE-HGF)9980$$2StatID$$aIF >= 80$$bNAT MED : 2022$$d2023-08-29
000259941 9201_ $$0I:(DE-2719)1110007$$kAG Haass$$lMolecular Neurodegeneration$$x0
000259941 9201_ $$0I:(DE-2719)1210001$$kAG Jucker$$lCell Biology of Neurological Diseases$$x1
000259941 980__ $$ajournal
000259941 980__ $$aVDB
000259941 980__ $$aUNRESTRICTED
000259941 980__ $$aI:(DE-2719)1110007
000259941 980__ $$aI:(DE-2719)1210001
000259941 9801_ $$aFullTexts