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@ARTICLE{Johnson:259941,
      author       = {Johnson, Erik C B and Bian, Shijia and Haque, Rafi U and
                      Carter, E Kathleen and Watson, Caroline M and Gordon, Brian
                      A and Ping, Lingyan and Duong, Duc M and Epstein, Michael P
                      and McDade, Eric and Barthélemy, Nicolas R and Karch,
                      Celeste M and Xiong, Chengjie and Cruchaga, Carlos and
                      Perrin, Richard J and Wingo, Aliza P and Wingo, Thomas S and
                      Chhatwal, Jasmeer P and Day, Gregory S and Noble, James M
                      and Berman, Sarah B and Martins, Ralph and Graff-Radford,
                      Neill R and Schofield, Peter R and Ikeuchi, Takeshi and
                      Mori, Hiroshi and Levin, Johannes and Farlow, Martin and
                      Lah, James J and Haass, Christian and Jucker, Mathias and
                      Morris, John C and Benzinger, Tammie L S and Roberts, Blaine
                      R and Bateman, Randall J and Fagan, Anne M and Seyfried,
                      Nicholas T and Levey, Allan I},
      collaboration = {Network, Dominantly Inherited Alzheimer},
      othercontributors = {Noble, James M and Day, Gregory S and Graff-Radford, Neill
                          R and Voglein, Jonathan and Allegri, Ricardo and Mendez,
                          Patricio Chrem and Surace, Ezequiel and Berman, Sarah B and
                          Ikonomovic, Snezana and Nadkarni, Neelesh and Lopera,
                          Francisco and Ramirez, Laura and Aguillon, David and Leon,
                          Yudy and Ramos, Claudia and Alzate, Diana and Baena, Ana and
                          Londono, Natalia and Moreno, Sonia and Laske, Christoph and
                          Kuder-Buletta, Elke and Graber-Sultan, Susanne and Preische,
                          Oliver and Hofmann, Anna and Ikeuchi, Takeshi and Kasuga,
                          Kensaku and Niimi, Yoshiki and Ishii, Kenji and Senda,
                          Michio and Sanchez-Valle, Raquel and Rosa-Neto, Pedro and
                          Fox, Nick and Cash, Dave and Lee, Jae-Hong and Roh, Jee Hoon
                          and Riddle, Meghan and Menard, William and Bodge, Courtney
                          and Surti, Mustafa and Takada, Leonel Tadao and Chhatwal,
                          Jasmeer P and Sanchez-Gonzalez, V. J. and Orozco-Barajas,
                          Maribel and Goate, Alison and Renton, Alan and Esposito,
                          Bianca and Karch, Celeste M and Marsh, Jacob and Cruchaga,
                          Carlos and Fernandez, Victoria and Gordon, Brian A and
                          Fagan, Anne M and Jerome, Gina and Herries, Elizabeth and
                          Llibre-Guerra, Jorge and Johnson, Erik C B and Seyfried,
                          Nicholas T and Schofield, Peter R and Brooks, William and
                          Bechara, Jacob and Bateman, Randall J and Hassenstab, Jason
                          and Perrin, Richard J and Franklin, Erin and Benzinger,
                          Tammie L S and Chen, Allison and Chen, Charles and Flores,
                          Shaney and Friedrichsen, Nelly and Hantler, Nancy and
                          Hornbeck, Russ and Jarman, Steve and Keefe, Sarah and
                          Koudelis, Deborah and Massoumzadeh, Parinaz and McCullough,
                          Austin and McKay, Nicole and Nicklaus, Joyce and Pulizos,
                          Christine and Wang, Qing and Mishall, Sheetal and
                          Sabaredzovic, Edita and Deng, Emily and Candela, Madison and
                          Smith, Hunter and Hobbs, Diana and Scott, Jalen and Levin,
                          Johannes and Xiong, Chengjie and Wang, Peter and Xu, Xiong
                          and Li, Yan and Gremminger, Emily and Ma, Yinjiao and Bui,
                          Ryan and Lu, Ruijin and Ortiz, Ana Luisa Sosa and Daniels,
                          Alisha and Courtney, Laura and Supnet-Bell, Charlene and Xu,
                          Jinbin and Ringman, John},
      title        = {{C}erebrospinal fluid proteomics define the natural history
                      of autosomal dominant {A}lzheimer's disease.},
      journal      = {Nature medicine},
      volume       = {29},
      number       = {8},
      issn         = {1078-8956},
      address      = {New York, NY},
      publisher    = {Nature America Inc.},
      reportid     = {DZNE-2023-00805},
      pages        = {1979 - 1988},
      year         = {2023},
      abstract     = {Alzheimer's disease (AD) pathology develops many years
                      before the onset of cognitive symptoms. Two pathological
                      processes-aggregation of the amyloid-β (Aβ) peptide into
                      plaques and the microtubule protein tau into neurofibrillary
                      tangles (NFTs)-are hallmarks of the disease. However, other
                      pathological brain processes are thought to be key disease
                      mediators of Aβ plaque and NFT pathology. How these
                      additional pathologies evolve over the course of the disease
                      is currently unknown. Here we show that proteomic
                      measurements in autosomal dominant AD cerebrospinal fluid
                      (CSF) linked to brain protein coexpression can be used to
                      characterize the evolution of AD pathology over a timescale
                      spanning six decades. SMOC1 and SPON1 proteins associated
                      with Aβ plaques were elevated in AD CSF nearly 30 years
                      before the onset of symptoms, followed by changes in
                      synaptic proteins, metabolic proteins, axonal proteins,
                      inflammatory proteins and finally decreases in
                      neurosecretory proteins. The proteome discriminated mutation
                      carriers from noncarriers before symptom onset as well or
                      better than Aβ and tau measures. Our results highlight the
                      multifaceted landscape of AD pathophysiology and its
                      temporal evolution. Such knowledge will be critical for
                      developing precision therapeutic interventions and
                      biomarkers for AD beyond those associated with Aβ and tau.},
      keywords     = {Alzheimer Disease: cerebrospinal fluid / Humans / Alzheimer
                      Disease: pathology / Proteomics / Amyloid beta-Peptides:
                      metabolism / tau Proteins: metabolism / Neurofibrillary
                      Tangles: pathology / Biomarkers: metabolism / Alzheimer
                      Disease: genetics / Alzheimer Disease: physiopathology /
                      Male / Female / Adult / Middle Aged / Mutation / Age of
                      Onset / SMOC1 protein, human (NLM Chemicals) / Amyloid
                      beta-Peptides (NLM Chemicals) / tau Proteins (NLM Chemicals)
                      / Biomarkers (NLM Chemicals)},
      cin          = {AG Haass / AG Jucker},
      ddc          = {610},
      cid          = {I:(DE-2719)1110007 / I:(DE-2719)1210001},
      pnm          = {352 - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-352},
      experiment   = {EXP:(DE-2719)DIAN-20090101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37550416},
      pmc          = {pmc:PMC10427428},
      doi          = {10.1038/s41591-023-02476-4},
      url          = {https://pub.dzne.de/record/259941},
}