TY  - JOUR
AU  - Babiloni, Claudio
AU  - Lopez, Susanna
AU  - Noce, Giuseppe
AU  - Ferri, Raffaele
AU  - Panerai, Simonetta
AU  - Catania, Valentina
AU  - Soricelli, Andrea
AU  - Salvatore, Marco
AU  - Nobili, Flavio
AU  - Arnaldi, Dario
AU  - Famà, Francesco
AU  - Massa, Federico
AU  - Buttinelli, Carla
AU  - Giubilei, Franco
AU  - Stocchi, Fabrizio
AU  - Vacca, Laura
AU  - Marizzoni, Moira
AU  - D'Antonio, Fabrizia
AU  - Bruno, Giuseppe
AU  - De Lena, Carlo
AU  - Güntekin, Bahar
AU  - Yıldırım, Ebru
AU  - Hanoğlu, Lutfu
AU  - Yener, Görsev
AU  - Yerlikaya, Deniz
AU  - Taylor, John Paul
AU  - Schumacher, Julia
AU  - McKeith, Ian
AU  - Bonanni, Laura
AU  - Pantano, Patrizia
AU  - Piervincenzi, Claudia
AU  - Petsas, Nikolaos
AU  - Frisoni, Giovanni B
AU  - Del Percio, Claudio
AU  - Carducci, Filippo
TI  - Relationship between default mode network and resting-state electroencephalographic alpha rhythms in cognitively unimpaired seniors and patients with dementia due to Alzheimer’s disease
JO  - Cerebral cortex
VL  - 33
IS  - 20
SN  - 1047-3211
CY  - Oxford
PB  - Oxford Univ. Press
M1  - DZNE-2023-00825
SP  - 10514 - 10527
PY  - 2023
AB  -  Here we tested the hypothesis of a relationship between the cortical default mode network (DMN) structural integrity and the resting-state electroencephalographic (rsEEG) rhythms in patients with Alzheimer's disease with dementia (ADD). Clinical and instrumental datasets in 45 ADD patients and 40 normal elderly (Nold) persons originated from the PDWAVES Consortium (www.pdwaves.eu). Individual rsEEG delta, theta, alpha, and fixed beta and gamma bands were considered. Freeware platforms served to derive (1) the (gray matter) volume of the DMN, dorsal attention (DAN), and sensorimotor (SMN) cortical networks and (2) the rsEEG cortical eLORETA source activities. We found a significant positive association between the DMN gray matter volume, the rsEEG alpha source activity estimated in the posterior DMN nodes (parietal and posterior cingulate cortex), and the global cognitive status in the Nold and ADD participants. Compared with the Nold, the ADD group showed lower DMN gray matter, lower rsEEG alpha source activity in those nodes, and lower global cognitive status. This effect was not observed in the DAN and SMN. These results suggest that the DMN structural integrity and the rsEEG alpha source activities in the DMN posterior hubs may be related and predict the global cognitive status in ADD and Nold persons.
KW  - Alzheimer’s disease with dementia (ADD) (Other)
KW  - Alzheimer’s disease with dementia (ADD) (Other)
KW  - Alzheimer’s disease with dementia (ADD) (Other)
KW  - Alzheimer’s disease with dementia (ADD) (Other)
KW  - Default mode network (DMN) (Other)
KW  - Exact low-resolution brain electromagnetic source tomography (eLORETA) (Other)
KW  - Resting state electroencephalographic (rsEEG) alpha rhythms (Other)
KW  - Structural magnetic resonance imaging (sMRI) (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:37615301
C2  - pmc:PMC10588004
DO  - DOI:10.1093/cercor/bhad300
UR  - https://pub.dzne.de/record/263549
ER  -