000263611 001__ 263611
000263611 005__ 20241203131416.0
000263611 020__ $$a978-1-0716-3436-3 (print)
000263611 020__ $$a978-1-0716-3437-0 (electronic)
000263611 0247_ $$2doi$$a10.1007/978-1-0716-3437-0_35
000263611 0247_ $$2pmid$$apmid:37639146
000263611 0247_ $$2ISSN$$a1064-3745
000263611 0247_ $$2ISSN$$a1940-6029
000263611 0247_ $$2altmetric$$aaltmetric:153401809
000263611 037__ $$aDZNE-2023-00833
000263611 041__ $$aEnglish
000263611 082__ $$a570
000263611 1001_ $$0P:(DE-2719)9001595$$aScholz, Rebekka$$b0$$eFirst author$$udzne
000263611 245__ $$aCombined Analysis of mRNA Expression and Open Chromatin in Microglia.
000263611 260__ $$aNew York, NY$$bSpringer US$$c2024
000263611 29510 $$aTissue-Resident Macrophages / Mass, Elvira (Editor) ; New York, NY : Springer US, 2024, Chapter 35 ; ISSN: 1064-3745=1940-6029 ; ISBN: 978-1-0716-3436-3=978-1-0716-3437-0 ; doi:10.1007/978-1-0716-3437-0
000263611 300__ $$a543 - 571
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000263611 3367_ $$0PUB:(DE-HGF)7$$2PUB:(DE-HGF)$$aContribution to a book$$bcontb$$mcontb$$s1733228043_30589
000263611 4900_ $$aMethods in Molecular Biology$$v2713
000263611 520__ $$aThe advance of single-cell RNA-sequencing technologies in the past years has enabled unprecedented insights into the complexity and heterogeneity of microglial cell states in the homeostatic and diseased brain. This includes rather complex proteomic, metabolomic, morphological, transcriptomic, and epigenetic adaptations to external stimuli and challenges resulting in a novel concept of core microglia properties and functions. To uncover the regulatory programs facilitating the rapid transcriptomic adaptation in response to changes in the local microenvironment, the accessibility of gene bodies and gene regulatory elements can be assessed. Here, we describe the application of a previously published method for simultaneous high-throughput ATAC and RNA expression with sequencing (SHARE-seq) on microglia nuclei isolated from frozen mouse brain tissue.
000263611 536__ $$0G:(DE-HGF)POF4-351$$a351 - Brain Function (POF4-351)$$cPOF4-351$$fPOF IV$$x0
000263611 536__ $$0G:(DE-HGF)POF4-352$$a352 - Disease Mechanisms (POF4-352)$$cPOF4-352$$fPOF IV$$x1
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000263611 650_7 $$2Other$$aBioinformatics
000263611 650_7 $$2Other$$aChromatin accessibility
000263611 650_7 $$2Other$$aEpigenetics
000263611 650_7 $$2Other$$aMicroglia
000263611 650_7 $$2Other$$aMultiomics
000263611 650_7 $$2Other$$aSingle-nucleus sequencing
000263611 650_7 $$2Other$$aTranscriptomics
000263611 650_7 $$2NLM Chemicals$$aChromatin
000263611 650_7 $$2NLM Chemicals$$aRNA, Messenger
000263611 650_7 $$063231-63-0$$2NLM Chemicals$$aRNA
000263611 650_2 $$2MeSH$$aAnimals
000263611 650_2 $$2MeSH$$aMice
000263611 650_2 $$2MeSH$$aChromatin: genetics
000263611 650_2 $$2MeSH$$aMicroglia
000263611 650_2 $$2MeSH$$aProteomics
000263611 650_2 $$2MeSH$$aRNA, Messenger: genetics
000263611 650_2 $$2MeSH$$aRNA
000263611 693__ $$0EXP:(DE-2719)PRECISE-20190321$$5EXP:(DE-2719)PRECISE-20190321$$ePlatform for Single Cell Genomics and Epigenomics at DZNE  University of Bonn$$x0
000263611 7001_ $$0P:(DE-2719)9000502$$aBrösamle, Desirée$$b1$$udzne
000263611 7001_ $$0P:(DE-2719)9002065$$aYuan, Xidi$$b2$$udzne
000263611 7001_ $$0P:(DE-2719)2811021$$aNeher, Jonas J$$b3$$udzne
000263611 7001_ $$0P:(DE-2719)2812219$$aBeyer, Marc$$b4$$eLast author$$udzne
000263611 773__ $$a10.1007/978-1-0716-3437-0_35
000263611 8564_ $$uhttps://pub.dzne.de/record/263611/files/DZNE-2023-00833_Restricted.pdf
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000263611 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9001595$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b0$$kDZNE
000263611 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9000502$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b1$$kDZNE
000263611 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9002065$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b2$$kDZNE
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000263611 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812219$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b4$$kDZNE
000263611 9131_ $$0G:(DE-HGF)POF4-351$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vBrain Function$$x0
000263611 9131_ $$0G:(DE-HGF)POF4-352$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vDisease Mechanisms$$x1
000263611 9141_ $$y2024
000263611 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2022-11-23
000263611 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2022-11-23
000263611 9201_ $$0I:(DE-2719)1013035$$kAG Beyer$$lImmunogenomics and Neurodegeneration$$x0
000263611 9201_ $$0I:(DE-2719)1210012$$kAG Neher (Tübingen)$$lNeuroimmunology and Neurodegenerative Disease$$x1
000263611 9201_ $$0I:(DE-2719)1013031$$kPRECISE$$lPlatform for Single Cell Genomics and Epigenomics$$x2
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