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001     263611
005     20241203131416.0
020 _ _ |a 978-1-0716-3436-3 (print)
020 _ _ |a 978-1-0716-3437-0 (electronic)
024 7 _ |a 10.1007/978-1-0716-3437-0_35
|2 doi
024 7 _ |a pmid:37639146
|2 pmid
024 7 _ |a 1064-3745
|2 ISSN
024 7 _ |a 1940-6029
|2 ISSN
024 7 _ |a altmetric:153401809
|2 altmetric
037 _ _ |a DZNE-2023-00833
041 _ _ |a English
082 _ _ |a 570
100 1 _ |a Scholz, Rebekka
|0 P:(DE-2719)9001595
|b 0
|e First author
|u dzne
245 _ _ |a Combined Analysis of mRNA Expression and Open Chromatin in Microglia.
260 _ _ |a New York, NY
|c 2024
|b Springer US
295 1 0 |a Tissue-Resident Macrophages / Mass, Elvira (Editor) ; New York, NY : Springer US, 2024, Chapter 35 ; ISSN: 1064-3745=1940-6029 ; ISBN: 978-1-0716-3436-3=978-1-0716-3437-0 ; doi:10.1007/978-1-0716-3437-0
300 _ _ |a 543 - 571
336 7 _ |a BOOK_CHAPTER
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336 7 _ |a Book Section
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336 7 _ |a bookPart
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336 7 _ |a INBOOK
|2 BibTeX
336 7 _ |a Output Types/Book chapter
|2 DataCite
336 7 _ |a Contribution to a book
|b contb
|m contb
|0 PUB:(DE-HGF)7
|s 1733228043_30589
|2 PUB:(DE-HGF)
490 0 _ |a Methods in Molecular Biology
|v 2713
520 _ _ |a The advance of single-cell RNA-sequencing technologies in the past years has enabled unprecedented insights into the complexity and heterogeneity of microglial cell states in the homeostatic and diseased brain. This includes rather complex proteomic, metabolomic, morphological, transcriptomic, and epigenetic adaptations to external stimuli and challenges resulting in a novel concept of core microglia properties and functions. To uncover the regulatory programs facilitating the rapid transcriptomic adaptation in response to changes in the local microenvironment, the accessibility of gene bodies and gene regulatory elements can be assessed. Here, we describe the application of a previously published method for simultaneous high-throughput ATAC and RNA expression with sequencing (SHARE-seq) on microglia nuclei isolated from frozen mouse brain tissue.
536 _ _ |a 351 - Brain Function (POF4-351)
|0 G:(DE-HGF)POF4-351
|c POF4-351
|f POF IV
|x 0
536 _ _ |a 352 - Disease Mechanisms (POF4-352)
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|c POF4-352
|f POF IV
|x 1
588 _ _ |a Dataset connected to CrossRef Book Series, PubMed, , Journals: pub.dzne.de
650 _ 7 |a Bioinformatics
|2 Other
650 _ 7 |a Chromatin accessibility
|2 Other
650 _ 7 |a Epigenetics
|2 Other
650 _ 7 |a Microglia
|2 Other
650 _ 7 |a Multiomics
|2 Other
650 _ 7 |a Single-nucleus sequencing
|2 Other
650 _ 7 |a Transcriptomics
|2 Other
650 _ 7 |a Chromatin
|2 NLM Chemicals
650 _ 7 |a RNA, Messenger
|2 NLM Chemicals
650 _ 7 |a RNA
|0 63231-63-0
|2 NLM Chemicals
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Mice
|2 MeSH
650 _ 2 |a Chromatin: genetics
|2 MeSH
650 _ 2 |a Microglia
|2 MeSH
650 _ 2 |a Proteomics
|2 MeSH
650 _ 2 |a RNA, Messenger: genetics
|2 MeSH
650 _ 2 |a RNA
|2 MeSH
693 _ _ |0 EXP:(DE-2719)PRECISE-20190321
|5 EXP:(DE-2719)PRECISE-20190321
|e Platform for Single Cell Genomics and Epigenomics at DZNE University of Bonn
|x 0
700 1 _ |a Brösamle, Desirée
|0 P:(DE-2719)9000502
|b 1
|u dzne
700 1 _ |a Yuan, Xidi
|0 P:(DE-2719)9002065
|b 2
|u dzne
700 1 _ |a Neher, Jonas J
|0 P:(DE-2719)2811021
|b 3
|u dzne
700 1 _ |a Beyer, Marc
|0 P:(DE-2719)2812219
|b 4
|e Last author
|u dzne
773 _ _ |a 10.1007/978-1-0716-3437-0_35
856 4 _ |u https://pub.dzne.de/record/263611/files/DZNE-2023-00833_Restricted.pdf
856 4 _ |u https://pub.dzne.de/record/263611/files/DZNE-2023-00833_Restricted.pdf?subformat=pdfa
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909 C O |p VDB
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 0
|6 P:(DE-2719)9001595
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 1
|6 P:(DE-2719)9000502
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
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|6 P:(DE-2719)9002065
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
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|6 P:(DE-2719)2811021
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 4
|6 P:(DE-2719)2812219
913 1 _ |a DE-HGF
|b Gesundheit
|l Neurodegenerative Diseases
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|0 G:(DE-HGF)POF4-351
|3 G:(DE-HGF)POF4
|2 G:(DE-HGF)POF4-300
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|v Brain Function
|x 0
913 1 _ |a DE-HGF
|b Gesundheit
|l Neurodegenerative Diseases
|1 G:(DE-HGF)POF4-350
|0 G:(DE-HGF)POF4-352
|3 G:(DE-HGF)POF4
|2 G:(DE-HGF)POF4-300
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|v Disease Mechanisms
|x 1
914 1 _ |y 2024
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0200
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|b SCOPUS
|d 2022-11-23
915 _ _ |a DBCoverage
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920 1 _ |0 I:(DE-2719)1013035
|k AG Beyer
|l Immunogenomics and Neurodegeneration
|x 0
920 1 _ |0 I:(DE-2719)1210012
|k AG Neher (Tübingen)
|l Neuroimmunology and Neurodegenerative Disease
|x 1
920 1 _ |0 I:(DE-2719)1013031
|k PRECISE
|l Platform for Single Cell Genomics and Epigenomics
|x 2
980 _ _ |a contb
980 _ _ |a VDB
980 _ _ |a I:(DE-2719)1013035
980 _ _ |a I:(DE-2719)1210012
980 _ _ |a I:(DE-2719)1013031
980 _ _ |a UNRESTRICTED

LibraryCollectionCLSMajorCLSMinorLanguageAuthor
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