TY  - JOUR
AU  - Hirsch-Reinshagen, Veronica
AU  - Hercher, Christa
AU  - Vila-Rodriguez, Fidel
AU  - Neumann, Manuela
AU  - Rademakers, Rosa
AU  - Honer, William G.
AU  - Hsiung, Ging-Yuek R.
AU  - Mackenzie, Ian R.
TI  - Psychotic symptoms in frontotemporal dementia with TDP‐43 tend to be associated with type B pathology
JO  - Neuropathology & applied neurobiology
VL  - 49
IS  - 4
SN  - 0305-1846
CY  - Oxford [u.a.]
PB  - Wiley-Blackwell
M1  - DZNE-2023-00841
SP  - e12921
PY  - 2023
AB  -  Psychotic symptoms are increasingly recognized as a distinguishing clinical feature in patients with dementia due to frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP). Within this group, carriers of the C9orf72 repeat expansion are particularly prone to develop delusions and hallucinations.The present retrospective study sought to provide novel details about the relationship between FTLD-TDP pathology and the presence of psychotic symptoms during life.We found that FTLD-TDP subtype B was more frequent in patients with psychotic symptoms than in those without. This relationship was present even when corrected for the presence of C9orf72 mutation, suggesting that pathophysiological processes leading to the development of subtype B pathology may increase the risk of psychotic symptoms. Within the group of FTLD-TDP cases with subtype B pathology, psychotic symptoms tended to be associated with a greater burden of TDP-43 pathology in the white matter and a lower burden in lower motor neurons. When present, pathological involvement of motor neurons was more likely to be asymptomatic in patients with psychosis.This work suggests that psychotic symptoms in patients with FTLD-TDP tend to be associated with subtype B pathology. This relationship is not completely explained by the effects of the C9orf72 mutation and raises the possibility of a direct link between psychotic symptoms and this particular pattern of TDP-43 pathology.
KW  - Humans
KW  - C9orf72 Protein: genetics
KW  - DNA-Binding Proteins: genetics
KW  - Frontotemporal Dementia: genetics
KW  - Frontotemporal Dementia: pathology
KW  - Frontotemporal Lobar Degeneration: pathology
KW  - Psychotic Disorders: complications
KW  - Retrospective Studies
KW  - ALS (Other)
KW  - FTLD-TDP (Other)
KW  - frontotemporal dementia (Other)
KW  - histology (Other)
KW  - psychosis (Other)
KW  - C9orf72 Protein (NLM Chemicals)
KW  - DNA-Binding Proteins (NLM Chemicals)
KW  - TARDBP protein, human (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C2  - pmc:PMC10527970
C6  - pmid:37386798
DO  - DOI:10.1111/nan.12921
UR  - https://pub.dzne.de/record/263619
ER  -