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@ARTICLE{HirschReinshagen:263619,
      author       = {Hirsch-Reinshagen, Veronica and Hercher, Christa and
                      Vila-Rodriguez, Fidel and Neumann, Manuela and Rademakers,
                      Rosa and Honer, William G. and Hsiung, Ging-Yuek R. and
                      Mackenzie, Ian R.},
      title        = {{P}sychotic symptoms in frontotemporal dementia with
                      {TDP}‐43 tend to be associated with type {B} pathology},
      journal      = {Neuropathology $\&$ applied neurobiology},
      volume       = {49},
      number       = {4},
      issn         = {0305-1846},
      address      = {Oxford [u.a.]},
      publisher    = {Wiley-Blackwell},
      reportid     = {DZNE-2023-00841},
      pages        = {e12921},
      year         = {2023},
      abstract     = {Psychotic symptoms are increasingly recognized as a
                      distinguishing clinical feature in patients with dementia
                      due to frontotemporal lobar degeneration with TDP-43
                      pathology (FTLD-TDP). Within this group, carriers of the
                      C9orf72 repeat expansion are particularly prone to develop
                      delusions and hallucinations.The present retrospective study
                      sought to provide novel details about the relationship
                      between FTLD-TDP pathology and the presence of psychotic
                      symptoms during life.We found that FTLD-TDP subtype B was
                      more frequent in patients with psychotic symptoms than in
                      those without. This relationship was present even when
                      corrected for the presence of C9orf72 mutation, suggesting
                      that pathophysiological processes leading to the development
                      of subtype B pathology may increase the risk of psychotic
                      symptoms. Within the group of FTLD-TDP cases with subtype B
                      pathology, psychotic symptoms tended to be associated with a
                      greater burden of TDP-43 pathology in the white matter and a
                      lower burden in lower motor neurons. When present,
                      pathological involvement of motor neurons was more likely to
                      be asymptomatic in patients with psychosis.This work
                      suggests that psychotic symptoms in patients with FTLD-TDP
                      tend to be associated with subtype B pathology. This
                      relationship is not completely explained by the effects of
                      the C9orf72 mutation and raises the possibility of a direct
                      link between psychotic symptoms and this particular pattern
                      of TDP-43 pathology.},
      keywords     = {Humans / C9orf72 Protein: genetics / DNA-Binding Proteins:
                      genetics / Frontotemporal Dementia: genetics /
                      Frontotemporal Dementia: pathology / Frontotemporal Lobar
                      Degeneration: pathology / Psychotic Disorders: complications
                      / Retrospective Studies / ALS (Other) / FTLD-TDP (Other) /
                      frontotemporal dementia (Other) / histology (Other) /
                      psychosis (Other) / C9orf72 Protein (NLM Chemicals) /
                      DNA-Binding Proteins (NLM Chemicals) / TARDBP protein, human
                      (NLM Chemicals)},
      cin          = {AG Neumann},
      ddc          = {610},
      cid          = {I:(DE-2719)1210003},
      pnm          = {352 - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pmc          = {pmc:PMC10527970},
      pubmed       = {pmid:37386798},
      doi          = {10.1111/nan.12921},
      url          = {https://pub.dzne.de/record/263619},
}