Home > Publications Database > Psychotic symptoms in frontotemporal dementia with TDP‐43 tend to be associated with type B pathology > print

001     263619
005     20240403131750.0
024 7 _ |a pmc:PMC10527970
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024 7 _ |a 10.1111/nan.12921
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024 7 _ |a 0305-1846
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024 7 _ |a 1365-2990
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037 _ _ |a DZNE-2023-00841
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Hirsch-Reinshagen, Veronica
|b 0
245 _ _ |a Psychotic symptoms in frontotemporal dementia with TDP‐43 tend to be associated with type B pathology
260 _ _ |a Oxford [u.a.]
|c 2023
|b Wiley-Blackwell
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520 _ _ |a Psychotic symptoms are increasingly recognized as a distinguishing clinical feature in patients with dementia due to frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP). Within this group, carriers of the C9orf72 repeat expansion are particularly prone to develop delusions and hallucinations.The present retrospective study sought to provide novel details about the relationship between FTLD-TDP pathology and the presence of psychotic symptoms during life.We found that FTLD-TDP subtype B was more frequent in patients with psychotic symptoms than in those without. This relationship was present even when corrected for the presence of C9orf72 mutation, suggesting that pathophysiological processes leading to the development of subtype B pathology may increase the risk of psychotic symptoms. Within the group of FTLD-TDP cases with subtype B pathology, psychotic symptoms tended to be associated with a greater burden of TDP-43 pathology in the white matter and a lower burden in lower motor neurons. When present, pathological involvement of motor neurons was more likely to be asymptomatic in patients with psychosis.This work suggests that psychotic symptoms in patients with FTLD-TDP tend to be associated with subtype B pathology. This relationship is not completely explained by the effects of the C9orf72 mutation and raises the possibility of a direct link between psychotic symptoms and this particular pattern of TDP-43 pathology.
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650 _ 7 |a ALS
|2 Other
650 _ 7 |a FTLD-TDP
|2 Other
650 _ 7 |a frontotemporal dementia
|2 Other
650 _ 7 |a histology
|2 Other
650 _ 7 |a psychosis
|2 Other
650 _ 7 |a C9orf72 Protein
|2 NLM Chemicals
650 _ 7 |a DNA-Binding Proteins
|2 NLM Chemicals
650 _ 7 |a TARDBP protein, human
|2 NLM Chemicals
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a C9orf72 Protein: genetics
|2 MeSH
650 _ 2 |a DNA-Binding Proteins: genetics
|2 MeSH
650 _ 2 |a Frontotemporal Dementia: genetics
|2 MeSH
650 _ 2 |a Frontotemporal Dementia: pathology
|2 MeSH
650 _ 2 |a Frontotemporal Lobar Degeneration: pathology
|2 MeSH
650 _ 2 |a Psychotic Disorders: complications
|2 MeSH
650 _ 2 |a Retrospective Studies
|2 MeSH
700 1 _ |a Hercher, Christa
|b 1
700 1 _ |a Vila-Rodriguez, Fidel
|b 2
700 1 _ |a Neumann, Manuela
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700 1 _ |a Rademakers, Rosa
|b 4
700 1 _ |a Honer, William G.
|b 5
700 1 _ |a Hsiung, Ging-Yuek R.
|b 6
700 1 _ |a Mackenzie, Ian R.
|b 7
773 _ _ |a 10.1111/nan.12921
|g Vol. 49, no. 4, p. e12921
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|t Neuropathology & applied neurobiology
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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