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000263802 041__ $$aEnglish
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000263802 1001_ $$aMichanski, Susann$$b0
000263802 245__ $$aPiccolino is required for ribbon architecture at cochlear inner hair cell synapses and for hearing.
000263802 260__ $$aHoboken, NJ [u.a.]$$bWiley$$c2023
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000263802 520__ $$aCochlear inner hair cells (IHCs) form specialized ribbon synapses with spiral ganglion neurons that tirelessly transmit sound information at high rates over long time periods with extreme temporal precision. This functional specialization is essential for sound encoding and is attributed to a distinct molecular machinery with unique players or splice variants compared to conventional neuronal synapses. Among these is the active zone (AZ) scaffold protein piccolo/aczonin, which is represented by its short splice variant piccolino at cochlear and retinal ribbon synapses. While the function of piccolo at synapses of the central nervous system has been intensively investigated, the role of piccolino at IHC synapses remains unclear. In this study, we characterize the structure and function of IHC synapses in piccolo gene-trap mutant rats (Pclogt/gt ). We find a mild hearing deficit with elevated thresholds and reduced amplitudes of auditory brainstem responses. Ca2+ channel distribution and ribbon morphology are altered in apical IHCs, while their presynaptic function seems to be unchanged. We conclude that piccolino contributes to the AZ organization in IHCs and is essential for normal hearing.
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000263802 650_7 $$2Other$$aCa2+ channel
000263802 650_7 $$2Other$$aactive zone
000263802 650_7 $$2Other$$acochlea
000263802 650_7 $$2Other$$ahearing
000263802 650_7 $$2Other$$asynaptic vesicle
000263802 650_7 $$2NLM Chemicals$$aPclo protein, rat
000263802 650_7 $$2NLM Chemicals$$aCytoskeletal Proteins
000263802 650_7 $$2NLM Chemicals$$aNeuropeptides
000263802 650_2 $$2MeSH$$aRats
000263802 650_2 $$2MeSH$$aAnimals
000263802 650_2 $$2MeSH$$aHair Cells, Auditory, Inner
000263802 650_2 $$2MeSH$$aHearing: physiology
000263802 650_2 $$2MeSH$$aSynapses: physiology
000263802 650_2 $$2MeSH$$aCochlea
000263802 650_2 $$2MeSH$$aSpiral Ganglion: metabolism
000263802 650_2 $$2MeSH$$aCytoskeletal Proteins: metabolism
000263802 650_2 $$2MeSH$$aNeuropeptides
000263802 7001_ $$00000-0002-4522-3289$$aKapoor, Rohan$$b1
000263802 7001_ $$00000-0002-4814-7517$$aSteyer, Anna M$$b2
000263802 7001_ $$aMöbius, Wiebke$$b3
000263802 7001_ $$aFrüholz, Iris$$b4
000263802 7001_ $$0P:(DE-2719)2810967$$aAckermann, Frauke$$b5$$udzne
000263802 7001_ $$aGültas, Mehmet$$b6
000263802 7001_ $$0P:(DE-2719)2810922$$aGarner, Craig C$$b7$$udzne
000263802 7001_ $$aHamra, F Kent$$b8
000263802 7001_ $$00000-0002-4757-9385$$aNeef, Jakob$$b9
000263802 7001_ $$00000-0003-1673-1046$$aStrenzke, Nicola$$b10
000263802 7001_ $$00000-0001-7145-0533$$aMoser, Tobias$$b11
000263802 7001_ $$00000-0001-8868-8716$$aWichmann, Carolin$$b12
000263802 773__ $$0PERI:(DE-600)2025376-X$$a10.15252/embr.202256702$$gVol. 24, no. 9, p. e56702$$n9$$pe56702$$tEMBO reports$$v24$$x1469-221X$$y2023
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