Home > Publications Database > Piccolino is required for ribbon architecture at cochlear inner hair cell synapses and for hearing. > print

001     263802
005     20231120155355.0
024 7 _ |a 10.15252/embr.202256702
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024 7 _ |a 1469-221X
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037 _ _ |a DZNE-2023-00888
041 _ _ |a English
082 _ _ |a 570
100 1 _ |a Michanski, Susann
|b 0
245 _ _ |a Piccolino is required for ribbon architecture at cochlear inner hair cell synapses and for hearing.
260 _ _ |a Hoboken, NJ [u.a.]
|c 2023
|b Wiley
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520 _ _ |a Cochlear inner hair cells (IHCs) form specialized ribbon synapses with spiral ganglion neurons that tirelessly transmit sound information at high rates over long time periods with extreme temporal precision. This functional specialization is essential for sound encoding and is attributed to a distinct molecular machinery with unique players or splice variants compared to conventional neuronal synapses. Among these is the active zone (AZ) scaffold protein piccolo/aczonin, which is represented by its short splice variant piccolino at cochlear and retinal ribbon synapses. While the function of piccolo at synapses of the central nervous system has been intensively investigated, the role of piccolino at IHC synapses remains unclear. In this study, we characterize the structure and function of IHC synapses in piccolo gene-trap mutant rats (Pclogt/gt ). We find a mild hearing deficit with elevated thresholds and reduced amplitudes of auditory brainstem responses. Ca2+ channel distribution and ribbon morphology are altered in apical IHCs, while their presynaptic function seems to be unchanged. We conclude that piccolino contributes to the AZ organization in IHCs and is essential for normal hearing.
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650 _ 7 |a Ca2+ channel
|2 Other
650 _ 7 |a active zone
|2 Other
650 _ 7 |a cochlea
|2 Other
650 _ 7 |a hearing
|2 Other
650 _ 7 |a synaptic vesicle
|2 Other
650 _ 7 |a Pclo protein, rat
|2 NLM Chemicals
650 _ 7 |a Cytoskeletal Proteins
|2 NLM Chemicals
650 _ 7 |a Neuropeptides
|2 NLM Chemicals
650 _ 2 |a Rats
|2 MeSH
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Hair Cells, Auditory, Inner
|2 MeSH
650 _ 2 |a Hearing: physiology
|2 MeSH
650 _ 2 |a Synapses: physiology
|2 MeSH
650 _ 2 |a Cochlea
|2 MeSH
650 _ 2 |a Spiral Ganglion: metabolism
|2 MeSH
650 _ 2 |a Cytoskeletal Proteins: metabolism
|2 MeSH
650 _ 2 |a Neuropeptides
|2 MeSH
700 1 _ |a Kapoor, Rohan
|0 0000-0002-4522-3289
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700 1 _ |a Steyer, Anna M
|0 0000-0002-4814-7517
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700 1 _ |a Möbius, Wiebke
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700 1 _ |a Früholz, Iris
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700 1 _ |a Ackermann, Frauke
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700 1 _ |a Gültas, Mehmet
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700 1 _ |a Garner, Craig C
|0 P:(DE-2719)2810922
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700 1 _ |a Hamra, F Kent
|b 8
700 1 _ |a Neef, Jakob
|0 0000-0002-4757-9385
|b 9
700 1 _ |a Strenzke, Nicola
|0 0000-0003-1673-1046
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700 1 _ |a Moser, Tobias
|0 0000-0001-7145-0533
|b 11
700 1 _ |a Wichmann, Carolin
|0 0000-0001-8868-8716
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773 _ _ |a 10.15252/embr.202256702
|g Vol. 24, no. 9, p. e56702
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