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@ARTICLE{Rufener:263985,
      author       = {Rufener, Katharina S and Wienke, Christian and Salanje,
                      Alena and Haghikia, Aiden and Zaehle, Tino},
      title        = {{E}ffects of transcutaneous auricular vagus nerve
                      stimulation paired with tones on electrophysiological
                      markers of auditory perception.},
      journal      = {Brain stimulation},
      volume       = {16},
      number       = {4},
      issn         = {1935-861X},
      address      = {New York, NY [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DZNE-2023-00919},
      pages        = {982 - 989},
      year         = {2023},
      abstract     = {Transcutaneous auricular vagus nerve stimulation (taVNS)
                      has been introduced as a non-invasive alternative to
                      invasive vagus nerve stimulation (iVNS). While iVNS paired
                      with tones has been highlighted as a potential effective
                      therapy for the treatment of auditory disorders such as
                      tinnitus, there is still scarce data available confirming
                      the efficacy of non-invasive taVNS. Here, we assessed the
                      effect of taVNS paired with acoustic stimuli on
                      sensory-related electrophysiological responses.A total of 22
                      healthy participants were investigated with a taVNS
                      tone-pairing paradigm using a within-subjects design. In a
                      single session pure tones paired with either active taVNS or
                      sham taVNS were repeatedly presented. Novel tones without
                      electrical stimulation served as control condition. Auditory
                      event related potentials and auditory cortex oscillations
                      were compared before and after the tone pairing procedure
                      between stimulation conditions.From pre to post pairing, we
                      observed a decrease in the N1 amplitude and in theta power
                      to tones paired with sham taVNS while these
                      electrophysiological measures remained stable for tones
                      paired with active taVNS a pattern mirroring auditory
                      sensory processing of novel, unpaired control tones.Our
                      results demonstrate the efficacy of a short-term application
                      of non-invasive taVNS to modulate auditory processing in
                      healthy individuals and, thereby, have potential
                      implications for interventions in auditory processing
                      deficits.},
      keywords     = {Humans / Vagus Nerve Stimulation: methods / Transcutaneous
                      Electric Nerve Stimulation: methods / Auditory Perception /
                      Electric Stimulation / Auditory Cortex: physiology / Vagus
                      Nerve: physiology / Biomarkers / Biomarkers (NLM Chemicals)
                      / Auditory cortex (Other) / Tone pairing (Other) /
                      Transcutaneous vagus nerve stimulation (Other)},
      cin          = {AG Düzel},
      ddc          = {610},
      cid          = {I:(DE-2719)5000006},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37336282},
      doi          = {10.1016/j.brs.2023.06.006},
      url          = {https://pub.dzne.de/record/263985},
}