TY  - JOUR
AU  - Xylaki, Mary
AU  - Chopra, Avika
AU  - Weber, Sandrina
AU  - Bartl, Michael
AU  - Outeiro, Tiago F
AU  - Mollenhauer, Brit
TI  - Extracellular Vesicles for the Diagnosis of Parkinson's Disease: Systematic Review and Meta-Analysis.
JO  - Movement disorders
VL  - 38
IS  - 9
SN  - 0885-3185
CY  - New York, NY
PB  - Wiley
M1  - DZNE-2023-00922
SP  - 1585 - 1597
PY  - 2023
AB  - Parkinson's disease (PD) biomarkers are needed by both clinicians and researchers (for diagnosis, identifying study populations, and monitoring therapeutic response). Imaging, genetic, and biochemical biomarkers have been widely studied. In recent years, extracellular vesicles (EVs) have become a promising material for biomarker development. Proteins and molecular material from any organ, including the central nervous system, can be packed into EVs and transported to the periphery into easily obtainable biological specimens like blood, urine, and saliva. We performed a systematic review and meta-analysis of articles (published before November 15, 2022) reporting biomarker assessment in EVs in PD patients and healthy controls (HCs). Biomarkers were analyzed using random effects meta-analysis and the calculated standardized mean difference (Std.MD). Several proteins and ribonucleic acids have been identified in EVs in PD patients, but only α-synuclein (aSyn) and leucine-rich repeat kinase 2 (LRRK2) were reported in sufficient studies (n = 24 and 6, respectively) to perform a meta-analysis. EV aSyn was significantly increased in neuronal L1 cell adhesion molecule (L1CAM)-positive blood EVs in PD patients compared to HCs (Std.MD = 1.84, 95
KW  - Humans
KW  - Parkinson Disease: metabolism
KW  - Neural Cell Adhesion Molecule L1: metabolism
KW  - alpha-Synuclein: metabolism
KW  - Extracellular Vesicles: metabolism
KW  - Biomarkers
KW  - Sexually Transmitted Diseases: metabolism
KW  - α-synuclein (Other)
KW  - α-synuclein (Other)
KW  - L1 cell adhesion molecule (Other)
KW  - Parkinson's disease (Other)
KW  - biomarker (Other)
KW  - exosomes (Other)
KW  - plasma (Other)
KW  - α-synuclein (Other)
KW  - Neural Cell Adhesion Molecule L1 (NLM Chemicals)
KW  - alpha-Synuclein (NLM Chemicals)
KW  - Biomarkers (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:37449706
DO  - DOI:10.1002/mds.29497
UR  - https://pub.dzne.de/record/263988
ER  -