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@ARTICLE{Docherty:265360,
author = {Docherty, Anna R. and Mullins, Niamh and Ashley-Koch,
Allison E. and Qin, Xuejun and Coleman, Jonathan R. I. and
Shabalin, Andrey and Kang, JooEun and Murnyak, Balasz and
Wendt, Frank and Adams, Mark and Campos, Adrian I. and
DiBlasi, Emily and Fullerton, Janice M. and Kranzler, Henry
R. and Bakian, Amanda V. and Monson, Eric T. and Rentería,
Miguel E. and Walss-Bass, Consuelo and Andreassen, Ole A.
and Behera, Chittaranjan and Bulik, Cynthia M. and Edenberg,
Howard J. and Kessler, Ronald C. and Mann, J. John and
Nurnberger, John I. and Pistis, Giorgio and Streit, Fabian
and Ursano, Robert J. and Polimanti, Renato and Dennis,
Michelle and Garrett, Melanie and Hair, Lauren and Harvey,
Philip and Hauser, Elizabeth R. and Hauser, Michael A. and
Huffman, Jennifer and Jacobson, Daniel and Madduri, Ravi and
McMahon, Benjamin and Oslin, David W. and Trafton, Jodie and
Awasthi, Swapnil and Berrettini, Wade H. and Bohus, Martin
and Chang, Xiao and Chen, Hsi-Chung and Chen, Wei J. and
Christensen, Erik D. and Crow, Scott and Duriez, Philibert
and Edwards, Alexis C. and Fernández-Aranda, Fernando and
Galfalvy, Hanga and Gandal, Michael and Gorwood, Philip and
Guo, Yiran and Hafferty, Jonathan D. and Hakonarson, Hakon
and Halmi, Katherine A. and Hishimoto, Akitoyo and Jain,
Sonia and Jamain, Stéphane and Jiménez-Murcia, Susana and
Johnson, Craig and Kaplan, Allan S. and Kaye, Walter H. and
Keel, Pamela K. and Kennedy, James L. and Kim, Minsoo and
Klump, Kelly L. and Levey, Daniel F. and Li, Dong and Liao,
Shih-Cheng and Lieb, Klaus and Lilenfeld, Lisa and Marshall,
Christian R. and Mitchell, James E. and Okazaki, Satoshi and
Otsuka, Ikuo and Pinto, Dalila and Powers, Abigail and
Ramoz, Nicolas and Ripke, Stephan and Roepke, Stefan and
Rozanov, Vsevolod and Scherer, Stephen W. and Schmahl,
Christian and Sokolowski, Marcus and Starnawska, Anna and
Strober, Michael and Su, Mei-Hsin and Thornton, Laura M. and
Treasure, Janet and Ware, Erin B. and Watson, Hunna J. and
Witt, Stephanie H. and Woodside, D. Blake and Yilmaz, Zeynep
and Zillich, Lea and Adolfsson, Rolf and Agartz, Ingrid and
Alda, Martin and Alfredsson, Lars and Appadurai, Vivek and
Artigas, María Soler and Van der Auwera, Sandra and
Azevedo, M. Helena and Bass, Nicholas and Bau, Claiton H. D.
and Baune, Bernhard T. and Bellivier, Frank and Berger,
Klaus and Biernacka, Joanna M. and Bigdeli, Tim B. and
Binder, Elisabeth B. and Boehnke, Michael and Boks, Marco P.
and Braff, David L. and Bryant, Richard and Budde, Monika
and Byrne, Enda M. and Cahn, Wiepke and Castelao, Enrique
and Cervilla, Jorge A. and Chaumette, Boris and Corvin,
Aiden and Craddock, Nicholas and Djurovic, Srdjan and Foo,
Jerome C. and Forstner, Andreas J. and Frye, Mark and Gatt,
Justine M. and Giegling, Ina and Grabe, Hans J. and Green,
Melissa J. and Grevet, Eugenio H. and Grigoroiu-Serbanescu,
Maria and Gutierrez, Blanca and Guzman-Parra, Jose and
Hamshere, Marian L. and Hartmann, Annette M. and Hauser,
Joanna and Heilmann-Heimbach, Stefanie and Hoffmann, Per and
Ising, Marcus and Jones, Ian and Jones, Lisa A. and Jonsson,
Lina and Kahn, René S. and Kelsoe, John R. and Kendler,
Kenneth S. and Kloiber, Stefan and Koenen, Karestan C. and
Kogevinas, Manolis and Krebs, Marie-Odile and Landén,
Mikael and Leboyer, Marion and Lee, Phil H. and Levinson,
Douglas F. and Liao, Calwing and Lissowska, Jolanta and
Mayoral, Fermin and McElroy, Susan L. and McGrath, Patrick
and McGuffin, Peter and McQuillin, Andrew and Mehta, Divya
and Melle, Ingrid and Mitchell, Philip B. and Molina, Esther
and Morken, Gunnar and Nievergelt, Caroline and Nöthen,
Markus M. and O’Donovan, Michael C. and Ophoff, Roel A.
and Owen, Michael J. and Pato, Carlos and Pato, Michele T.
and Penninx, Brenda W. J. H. and Potash, James B. and Power,
Robert A. and Preisig, Martin and Quested, Digby and
Ramos-Quiroga, Josep Antoni and Reif, Andreas and Ribasés,
Marta and Richarte, Vanesa and Rietschel, Marcella and
Rivera, Margarita and Roberts, Andrea and Roberts, Gloria
and Rouleau, Guy A. and Rovaris, Diego L. and Sanders, Alan
R. and Schofield, Peter R. and Schulze, Thomas G. and Scott,
Laura J. and Serretti, Alessandro and Shi, Jianxin and
Sirignano, Lea and Sklar, Pamela and Smeland, Olav B. and
Smoller, Jordan W. and Sonuga-Barke, Edmund J. S. and
Trzaskowski, Maciej and Tsuang, Ming T. and Turecki, Gustavo
and Vilar-Ribó, Laura and Vincent, John B. and Völzke,
Henry and Walters, James T. R. and Weickert, Cynthia Shannon
and Weickert, Thomas W. and Weissman, Myrna M. and Williams,
Leanne M. and Wray, Naomi R. and Zai, Clement C. and Agerbo,
Esben and Børglum, Anders D. and Breen, Gerome and
Demontis, Ditte and Erlangsen, Annette and Gelernter, Joel
and Glatt, Stephen J. and Hougaard, David M. and Hwu,
Hai-Gwo and Kuo, Po-Hsiu and Lewis, Cathryn M. and Li,
Qingqin S. and Liu, Chih-Min and Martin, Nicholas G. and
McIntosh, Andrew M. and Medland, Sarah E. and Mors, Ole and
Nordentoft, Merete and Olsen, Catherine M. and Porteous,
David and Smith, Daniel J. and Stahl, Eli A. and Stein,
Murray B. and Wasserman, Danuta and Werge, Thomas and
Whiteman, David C. and Willour, Virginia and Coon, Hilary
and Beckham, Jean C. and Kimbrel, Nathan A. and Ruderfer,
Douglas M.},
title = {{GWAS} {M}eta-{A}nalysis of {S}uicide {A}ttempt:
{I}dentification of 12 {G}enome-{W}ide {S}ignificant {L}oci
and {I}mplication of {G}enetic {R}isks for {S}pecific
{H}ealth {F}actors},
journal = {The American journal of psychiatry},
volume = {180},
number = {10},
issn = {0002-953X},
address = {Stanford, Calif.},
publisher = {HighWire Press},
reportid = {DZNE-2023-00984},
pages = {723 - 738},
year = {2023},
abstract = {Suicidal behavior is heritable and is a major cause of
death worldwide. Two large-scale genome-wide association
studies (GWASs) recently discovered and cross-validated
genome-wide significant (GWS) loci for suicide attempt (SA).
The present study leveraged the genetic cohorts from both
studies to conduct the largest GWAS meta-analysis of SA to
date. Multi-ancestry and admixture-specific meta-analyses
were conducted within groups of significant African, East
Asian, and European ancestry admixtures.This study comprised
22 cohorts, including 43,871 SA cases and 915,025
ancestry-matched controls. Analytical methods across
multi-ancestry and individual ancestry admixtures included
inverse variance-weighted fixed-effects meta-analyses,
followed by gene, gene-set, tissue-set, and drug-target
enrichment, as well as summary-data-based Mendelian
randomization with brain expression quantitative trait loci
data, phenome-wide genetic correlation, and genetic causal
proportion analyses.Multi-ancestry and European ancestry
admixture GWAS meta-analyses identified 12 risk loci at p
values <5×10-8. These loci were mostly intergenic and
implicated DRD2, SLC6A9, FURIN, NLGN1, SOX5, PDE4B, and
CACNG2. The multi-ancestry SNP-based heritability estimate
of SA was $5.7\%$ on the liability scale (SE=0.003,
p=5.7×10-80). Significant brain tissue gene expression and
drug set enrichment were observed. There was shared genetic
variation of SA with attention deficit hyperactivity
disorder, smoking, and risk tolerance after conditioning SA
on both major depressive disorder and posttraumatic stress
disorder. Genetic causal proportion analyses implicated
shared genetic risk for specific health factors.This
multi-ancestry analysis of suicide attempt identified
several loci contributing to risk and establishes
significant shared genetic covariation with clinical
phenotypes. These findings provide insight into genetic
factors associated with suicide attempt across ancestry
admixture populations, in veteran and civilian populations,
and in attempt versus death.},
keywords = {Humans / Genome-Wide Association Study / Suicide, Attempted
/ Depressive Disorder, Major: genetics / Risk Factors /
Suicidal Ideation / Polymorphism, Single Nucleotide:
genetics / Genetic Predisposition to Disease: genetics /
Genetic Loci: genetics / Biological Markers (Other) /
Depressive Disorders (Other) / Genetics (Other) /
Schizophrenia Spectrum and Other Psychotic Disorders (Other)
/ Self-Harm (Other) / Suicide (Other)},
cin = {AG Grabe / AG Hoffmann},
ddc = {610},
cid = {I:(DE-2719)5000001 / I:(DE-2719)1510600},
pnm = {353 - Clinical and Health Care Research (POF4-353)},
pid = {G:(DE-HGF)POF4-353},
typ = {PUB:(DE-HGF)16},
pmc = {pmc:PMC10603363},
pubmed = {pmid:37777856},
doi = {10.1176/appi.ajp.21121266},
url = {https://pub.dzne.de/record/265360},
}
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