TY  - JOUR
AU  - Rauchmann, Boris-Stephan
AU  - Gross, Patrizia
AU  - Ersoezlue, Ersin
AU  - Wagner, Michael
AU  - Ballarini, Tommaso
AU  - Kurz, Carolin
AU  - Tatò, Maia
AU  - Utecht, Julia
AU  - Papazov, Boris
AU  - Guersel, Selim
AU  - Totzke, Marie
AU  - Trappmann, Lena
AU  - Burow, Lena
AU  - Koller, Gabriele
AU  - Stöcklein, Sophia
AU  - Keeser, Daniel
AU  - Altenstein, Slawek
AU  - Bartels, Claudia
AU  - Buerger, Katharina
AU  - Dechent, Peter
AU  - Dobisch, Laura
AU  - Ewers, Michael
AU  - Fliessbach, Klaus
AU  - Freiesleben, Silka Dawn
AU  - Glanz, Wenzel
AU  - Görß, Doreen
AU  - Gref, Daria
AU  - Haynes, John Dylan
AU  - Janowitz, Daniel
AU  - Kilimann, Ingo
AU  - Kimmich, Okka
AU  - Kleineidam, Luca
AU  - Laske, Christoph
AU  - Lohse, Andrea
AU  - Maier, Franziska
AU  - Metzger, Coraline D.
AU  - Munk, Matthias H.
AU  - Peters, Oliver
AU  - Preis, Lukas
AU  - Priller, Josef
AU  - Roeske, Sandra
AU  - Roy, Nina
AU  - Sanzenbacher, Carolin
AU  - Scheffler, Klaus
AU  - Schneider, Anja
AU  - Schott, Björn Hendrik
AU  - Spottke, Annika
AU  - Spruth, Eike Jakob
AU  - Teipel, Stefan
AU  - van Lent, Debora Melo
AU  - Wiltfang, Jens
AU  - Wolfsgruber, Steffen
AU  - Yakupov, Renat
AU  - Düzel, Emrah
AU  - Jessen, Frank
AU  - Perneczky, Robert
TI  - A 6-items Questionnaire (6-QMD) captures a Mediterranean like dietary pattern and is associated with memory performance and hippocampal volume in elderly and persons at risk for Alzheimer’s disease
JO  - Nutrition and healthy aging
VL  - 8
IS  - 1
SN  - 2451-9480
CY  - Amsterdam
PB  - IOS Press
M1  - DZNE-2023-01014
SP  - 143 - 156
PY  - 2023
AB  - There is evidence that adherence to Mediterranean-like diet reduces cognitive decline and brain atrophy in Alzheimer's disease (AD). However, lengthy dietary assessments, such as food frequency questionnaires (FFQs), discourage more frequent use.OBJECTIVE:Here we aimed to validate a 6-items short questionnaire for a Mediterranean-like diet (6-QMD) and explore its associations with memory performance and hippocampal atrophy in healthy elders and individuals at risk for AD.METHODS:We analyzed 938 participants (N = 234 healthy controls and N = 704 participants with an increased AD risk) from the DZNE-Longitudinal Cognitive Impairment and Dementia Study (DELCODE). The 6-QMD was validated against the Mediterranean Diet (MeDi) score and the Mediterranean-DASH Diet Intervention for Neurodegenerative Delay (MIND) score, both derived from a detailed FFQ. Furthermore, associations between the 6-QMD and memory function as well as hippocampal atrophy were evaluated using linear regressions.RESULTS:The 6-QMD was moderately associated with the FFQ-derived MeDi adherence score (ρ = 0.25, p < 0.001) and the MIND score (ρ = 0.37, p= < 0.001). Higher fish and olive oil consumption and lower meat and sausage consumption showed significant associations in a linear regression, adjusted for diagnosis, age, sex and education, with memory function (β = 0.1, p = 0.008) and bilateral hippocampal volumes (left: β = 0.15, p < 0.001); (right: β = 0.18, p < 0.001)).CONCLUSIONS:The 6-QMD is a useful and valid brief tool to assess the adherence to MeDi and MIND diets, capturing associations with memory function and brain atrophy in healthy elders and individuals at increased AD dementia risk, making it a valid alternative in settings with time constraints.
LB  - PUB:(DE-HGF)16
DO  - DOI:10.3233/NHA-220190
UR  - https://pub.dzne.de/record/265665
ER  -