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000265757 1001_ $$0P:(DE-2719)2700762$$aEhret, Fanny$$b0$$eFirst author$$udzne
000265757 245__ $$aPresymptomatic Reduction of Individuality in the AppNL-F Knockin Model of Alzheimer's Disease.
000265757 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2023
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000265757 520__ $$aOne-third of the risk for Alzheimer's disease is explained by environment and lifestyle, but Alzheimer's disease pathology might also affect lifestyle and thereby impair the individual potential for health behavior and prevention.We examined in mice how the AppNL-F/NL-F (NL-F) knockin mutation affects the presymptomatic response to environmental enrichment (ENR) as an experimental paradigm addressing nongenetic factors. We assessed the emergence of interindividual phenotypic variation under the condition that both the genetic background and the shared environment were held constant, thereby isolating the contribution of individual behavior (nonshared environment).After 4 months of ENR, the mean and variability of plasma ApoE were increased in NL-F mice, suggesting a presymptomatic variation in pathogenic processes. Roaming entropy as a measure of behavioral activity was continuously assessed with radiofrequency identification (RFID) technology and revealed reduced habituation and variance in NL-F mice compared with control animals, which do not carry a Beyreuther/Iberian mutation. Intraindividual variation decreased, while behavioral stability was reduced in NL-F mice. Seven months after discontinuation of ENR, we found no difference in plaque size and number, but ENR increased variance in hippocampal plaque counts in NL-F mice. A reactive increase in adult hippocampal neurogenesis in NL-F mice, known from other models, was normalized by ENR.Our data suggest that while NL-F has early effects on individual behavioral patterns in response to ENR, there are lasting effects on cellular plasticity even after the discontinuation of ENR. Hence, early behavior matters for maintaining individual behavioral trajectories and brain plasticity even under maximally constrained conditions.
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000265757 650_7 $$2Other$$aAdult neurogenesis
000265757 650_7 $$2Other$$aDementia
000265757 650_7 $$2Other$$aHippocampus
000265757 650_7 $$2Other$$aLearning
000265757 650_7 $$2Other$$aReserve
000265757 650_7 $$2Other$$aVariability
000265757 650_7 $$2NLM Chemicals$$aAmyloid beta-Protein Precursor
000265757 650_7 $$2NLM Chemicals$$aAmyloid beta-Peptides
000265757 650_2 $$2MeSH$$aMice
000265757 650_2 $$2MeSH$$aAnimals
000265757 650_2 $$2MeSH$$aAlzheimer Disease: genetics
000265757 650_2 $$2MeSH$$aAlzheimer Disease: pathology
000265757 650_2 $$2MeSH$$aAmyloid beta-Protein Precursor: genetics
000265757 650_2 $$2MeSH$$aAmyloid beta-Peptides
000265757 650_2 $$2MeSH$$aIndividuality
000265757 650_2 $$2MeSH$$aMobile Applications
000265757 650_2 $$2MeSH$$aMice, Transgenic
000265757 650_2 $$2MeSH$$aDisease Models, Animal
000265757 7001_ $$0P:(DE-2719)9001397$$aPelz, Meike S$$b1$$udzne
000265757 7001_ $$0P:(DE-2719)9002273$$aSenko, Anna N$$b2
000265757 7001_ $$0P:(DE-HGF)0$$aSoto, Karla E G$$b3
000265757 7001_ $$0P:(DE-2719)9001845$$aLiu, Hang$$b4$$udzne
000265757 7001_ $$0P:(DE-2719)2000011$$aKempermann, Gerd$$b5$$eLast author$$udzne
000265757 773__ $$0PERI:(DE-600)1499907-9$$a10.1016/j.biopsych.2023.04.009$$gVol. 94, no. 9, p. 721 - 731$$n9$$p721 - 731$$tBiological psychiatry$$v94$$x0006-3223$$y2023
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