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@ARTICLE{Ehret:265757,
      author       = {Ehret, Fanny and Pelz, Meike S and Senko, Anna N and Soto,
                      Karla E G and Liu, Hang and Kempermann, Gerd},
      title        = {{P}resymptomatic {R}eduction of {I}ndividuality in the
                      {A}pp{NL}-{F} {K}nockin {M}odel of {A}lzheimer's {D}isease.},
      journal      = {Biological psychiatry},
      volume       = {94},
      number       = {9},
      issn         = {0006-3223},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DZNE-2023-01032},
      pages        = {721 - 731},
      year         = {2023},
      abstract     = {One-third of the risk for Alzheimer's disease is explained
                      by environment and lifestyle, but Alzheimer's disease
                      pathology might also affect lifestyle and thereby impair the
                      individual potential for health behavior and prevention.We
                      examined in mice how the AppNL-F/NL-F (NL-F) knockin
                      mutation affects the presymptomatic response to
                      environmental enrichment (ENR) as an experimental paradigm
                      addressing nongenetic factors. We assessed the emergence of
                      interindividual phenotypic variation under the condition
                      that both the genetic background and the shared environment
                      were held constant, thereby isolating the contribution of
                      individual behavior (nonshared environment).After 4 months
                      of ENR, the mean and variability of plasma ApoE were
                      increased in NL-F mice, suggesting a presymptomatic
                      variation in pathogenic processes. Roaming entropy as a
                      measure of behavioral activity was continuously assessed
                      with radiofrequency identification (RFID) technology and
                      revealed reduced habituation and variance in NL-F mice
                      compared with control animals, which do not carry a
                      Beyreuther/Iberian mutation. Intraindividual variation
                      decreased, while behavioral stability was reduced in NL-F
                      mice. Seven months after discontinuation of ENR, we found no
                      difference in plaque size and number, but ENR increased
                      variance in hippocampal plaque counts in NL-F mice. A
                      reactive increase in adult hippocampal neurogenesis in NL-F
                      mice, known from other models, was normalized by ENR.Our
                      data suggest that while NL-F has early effects on individual
                      behavioral patterns in response to ENR, there are lasting
                      effects on cellular plasticity even after the
                      discontinuation of ENR. Hence, early behavior matters for
                      maintaining individual behavioral trajectories and brain
                      plasticity even under maximally constrained conditions.},
      keywords     = {Mice / Animals / Alzheimer Disease: genetics / Alzheimer
                      Disease: pathology / Amyloid beta-Protein Precursor:
                      genetics / Amyloid beta-Peptides / Individuality / Mobile
                      Applications / Mice, Transgenic / Disease Models, Animal /
                      Adult neurogenesis (Other) / Dementia (Other) / Hippocampus
                      (Other) / Learning (Other) / Reserve (Other) / Variability
                      (Other) / Amyloid beta-Protein Precursor (NLM Chemicals) /
                      Amyloid beta-Peptides (NLM Chemicals)},
      cin          = {AG Kempermann},
      ddc          = {610},
      cid          = {I:(DE-2719)1710001},
      pnm          = {352 - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37076091},
      doi          = {10.1016/j.biopsych.2023.04.009},
      url          = {https://pub.dzne.de/record/265757},
}