%0 Journal Article
%A Rizig, Mie
%A Bandres-Ciga, Sara
%A Makarious, Mary B
%A Ojo, Oluwadamilola Omolara
%A Crea, Peter Wild
%A Abiodun, Oladunni Victoria
%A Levine, Kristin S
%A Abubakar, Sani Atta
%A Achoru, Charles Obiora
%A Vitale, Dan
%A Adeniji, Olaleye Akinmola
%A Agabi, Osigwe Paul
%A Koretsky, Mathew J
%A Agulanna, Uchechi
%A Hall, Deborah A
%A Akinyemi, Rufus Olusola
%A Xie, Tao
%A Ali, Mohammed Wulgo
%A Shamim, Ejaz A
%A Ani-Osheku, Ifeyinwa
%A Padmanaban, Mahesh
%A Arigbodi, Ohwotemu Michael
%A Standaert, David G
%A Bello, Abiodun Hamzat
%A Dean, Marissa N
%A Erameh, Cyril Oshomah
%A Elsayed, Inas
%A Farombi, Temitope Hannah
%A Okunoye, Olaitan
%A Fawale, Michael Bimbola
%A Billingsley, Kimberley J
%A Imarhiagbe, Frank Aiwansoba
%A Jerez, Pilar Alvarez
%A Iwuozo, Emmanuel Uzodinma
%A Baker, Breeana
%A Komolafe, Morenikeji Adeyoyin
%A Malik, Laksh
%A Nwani, Paul Osemeke
%A Daida, Kensuke
%A Nwazor, Ernest Okwundu
%A Miano-Burkhardt, Abigail
%A Nyandaiti, Yakub Wilberforce
%A Fang, Zih-Hua
%A Obiabo, Yahaya Olugbo
%A Kluss, Jillian H
%A Odeniyi, Olanike Adedoyin
%A Hernandez, Dena G
%A Odiase, Francis Ehidiamen
%A Tayebi, Nahid
%A Ojini, Francis Ibe
%A Sidranksy, Ellen
%A Onwuegbuzie, Gerald Awele
%A D'Souza, Andrea M
%A Osaigbovo, Godwin Osawaru
%A Berhe, Bahafta
%A Osemwegie, Nosakhare
%A Reed, Xylena
%A Oshinaike, Olajumoke Olufemi
%A Leonard, Hampton L
%A Otubogun, Folajimi Morenikeji
%A Alvarado, Chelsea X
%A Oyakhire, Shyngle Imiewan
%A Ozomma, Simon Izuchukwu
%A Samuel, Sarah Chabiri
%A Taiwo, Funmilola Tolulope
%A Wahab, Kolawole Wasiu
%A Zubair, Yusuf Agboola
%A Iwaki, Hirotaka
%A Kim, Jonggeol Jeffrey
%A Morris, Huw R
%A Hardy, John
%A Nalls, Mike A
%A Heilbron, Karl
%A Norcliffe-Kaufmann, Lucy
%A Black
%A Blauwendraat, Cornelis
%A Houlden, Henry
%A Singleton, Andrew
%A Okubadejo, Njideka Ulunma
%T Identification of genetic risk loci and causal insights associated with Parkinson's disease in African and African admixed populations: a genome-wide association study.
%J The lancet
%V 22
%N 11
%@ 1474-4422
%C London
%I Lancet Publ. Group
%M DZNE-2023-01035
%P 1015 - 1025
%D 2023
%X An understanding of the genetic mechanisms underlying diseases in ancestrally diverse populations is an important step towards development of targeted treatments. Research in African and African admixed populations can enable mapping of complex traits, because of their genetic diversity, extensive population substructure, and distinct linkage disequilibrium patterns. We aimed to do a comprehensive genome-wide assessment in African and African admixed individuals to better understand the genetic architecture of Parkinson's disease in these underserved populations.We performed a genome-wide association study (GWAS) in people of African and African admixed ancestry with and without Parkinson's disease. Individuals were included from several cohorts that were available as a part of the Global Parkinson's Genetics Program, the International Parkinson's Disease Genomics Consortium Africa, and 23andMe. A diagnosis of Parkinson's disease was confirmed clinically by a movement disorder specialist for every individual in each cohort, except for 23andMe, in which it was self-reported based on clinical diagnosis. We characterised ancestry-specific risk, differential haplotype structure and admixture, coding and structural genetic variation, and enzymatic activity.We included 197 918 individuals (1488 cases and 196 430 controls) in our genome-wide analysis. We identified a novel common risk factor for Parkinson's disease (overall meta-analysis odds ratio for risk of Parkinson's disease 1·58 [95
%K Parkinson Disease: ethnology
%K Humans
%K Parkinson Disease: genetics
%K Genome-Wide Association Study
%K Genetic Loci
%K Linkage Disequilibrium
%K Black People: genetics
%K Polymorphism, Single Nucleotide: genetics
%K Genetic Predisposition to Disease: genetics
%K African People: genetics
%K GBA protein, human (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:37633302
%2 pmc:PMC10593199
%R 10.1016/S1474-4422(23)00283-1
%U https://pub.dzne.de/record/265764