TY  - JOUR
AU  - Rizig, Mie
AU  - Bandres-Ciga, Sara
AU  - Makarious, Mary B
AU  - Ojo, Oluwadamilola Omolara
AU  - Crea, Peter Wild
AU  - Abiodun, Oladunni Victoria
AU  - Levine, Kristin S
AU  - Abubakar, Sani Atta
AU  - Achoru, Charles Obiora
AU  - Vitale, Dan
AU  - Adeniji, Olaleye Akinmola
AU  - Agabi, Osigwe Paul
AU  - Koretsky, Mathew J
AU  - Agulanna, Uchechi
AU  - Hall, Deborah A
AU  - Akinyemi, Rufus Olusola
AU  - Xie, Tao
AU  - Ali, Mohammed Wulgo
AU  - Shamim, Ejaz A
AU  - Ani-Osheku, Ifeyinwa
AU  - Padmanaban, Mahesh
AU  - Arigbodi, Ohwotemu Michael
AU  - Standaert, David G
AU  - Bello, Abiodun Hamzat
AU  - Dean, Marissa N
AU  - Erameh, Cyril Oshomah
AU  - Elsayed, Inas
AU  - Farombi, Temitope Hannah
AU  - Okunoye, Olaitan
AU  - Fawale, Michael Bimbola
AU  - Billingsley, Kimberley J
AU  - Imarhiagbe, Frank Aiwansoba
AU  - Jerez, Pilar Alvarez
AU  - Iwuozo, Emmanuel Uzodinma
AU  - Baker, Breeana
AU  - Komolafe, Morenikeji Adeyoyin
AU  - Malik, Laksh
AU  - Nwani, Paul Osemeke
AU  - Daida, Kensuke
AU  - Nwazor, Ernest Okwundu
AU  - Miano-Burkhardt, Abigail
AU  - Nyandaiti, Yakub Wilberforce
AU  - Fang, Zih-Hua
AU  - Obiabo, Yahaya Olugbo
AU  - Kluss, Jillian H
AU  - Odeniyi, Olanike Adedoyin
AU  - Hernandez, Dena G
AU  - Odiase, Francis Ehidiamen
AU  - Tayebi, Nahid
AU  - Ojini, Francis Ibe
AU  - Sidranksy, Ellen
AU  - Onwuegbuzie, Gerald Awele
AU  - D'Souza, Andrea M
AU  - Osaigbovo, Godwin Osawaru
AU  - Berhe, Bahafta
AU  - Osemwegie, Nosakhare
AU  - Reed, Xylena
AU  - Oshinaike, Olajumoke Olufemi
AU  - Leonard, Hampton L
AU  - Otubogun, Folajimi Morenikeji
AU  - Alvarado, Chelsea X
AU  - Oyakhire, Shyngle Imiewan
AU  - Ozomma, Simon Izuchukwu
AU  - Samuel, Sarah Chabiri
AU  - Taiwo, Funmilola Tolulope
AU  - Wahab, Kolawole Wasiu
AU  - Zubair, Yusuf Agboola
AU  - Iwaki, Hirotaka
AU  - Kim, Jonggeol Jeffrey
AU  - Morris, Huw R
AU  - Hardy, John
AU  - Nalls, Mike A
AU  - Heilbron, Karl
AU  - Norcliffe-Kaufmann, Lucy
AU  - Black
AU  - Blauwendraat, Cornelis
AU  - Houlden, Henry
AU  - Singleton, Andrew
AU  - Okubadejo, Njideka Ulunma
TI  - Identification of genetic risk loci and causal insights associated with Parkinson's disease in African and African admixed populations: a genome-wide association study.
JO  - The lancet
VL  - 22
IS  - 11
SN  - 1474-4422
CY  - London
PB  - Lancet Publ. Group
M1  - DZNE-2023-01035
SP  - 1015 - 1025
PY  - 2023
AB  - An understanding of the genetic mechanisms underlying diseases in ancestrally diverse populations is an important step towards development of targeted treatments. Research in African and African admixed populations can enable mapping of complex traits, because of their genetic diversity, extensive population substructure, and distinct linkage disequilibrium patterns. We aimed to do a comprehensive genome-wide assessment in African and African admixed individuals to better understand the genetic architecture of Parkinson's disease in these underserved populations.We performed a genome-wide association study (GWAS) in people of African and African admixed ancestry with and without Parkinson's disease. Individuals were included from several cohorts that were available as a part of the Global Parkinson's Genetics Program, the International Parkinson's Disease Genomics Consortium Africa, and 23andMe. A diagnosis of Parkinson's disease was confirmed clinically by a movement disorder specialist for every individual in each cohort, except for 23andMe, in which it was self-reported based on clinical diagnosis. We characterised ancestry-specific risk, differential haplotype structure and admixture, coding and structural genetic variation, and enzymatic activity.We included 197 918 individuals (1488 cases and 196 430 controls) in our genome-wide analysis. We identified a novel common risk factor for Parkinson's disease (overall meta-analysis odds ratio for risk of Parkinson's disease 1·58 [95
KW  - Parkinson Disease: ethnology
KW  - Humans
KW  - Parkinson Disease: genetics
KW  - Genome-Wide Association Study
KW  - Genetic Loci
KW  - Linkage Disequilibrium
KW  - Black People: genetics
KW  - Polymorphism, Single Nucleotide: genetics
KW  - Genetic Predisposition to Disease: genetics
KW  - African People: genetics
KW  - GBA protein, human (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:37633302
C2  - pmc:PMC10593199
DO  - DOI:10.1016/S1474-4422(23)00283-1
UR  - https://pub.dzne.de/record/265764
ER  -