%0 Journal Article
%A Wattjes, Mike P
%A Huppertz, Hans-Jürgen
%A Mahmoudi, Nima
%A Stöcklein, Sophia
%A Rogozinski, Sophia
%A Wegner, Florian
%A Klietz, Martin
%A Apostolova, Ivayla
%A Levin, Johannes
%A Katzdobler, Sabrina
%A Buhmann, Carsten
%A Quattrone, Andrea
%A Berding, Georg
%A Brendel, Matthias
%A Barthel, Henryk
%A Sabri, Osama
%A Höglinger, Günter
%A Buchert, Ralph
%T Brain MRI in Progressive Supranuclear Palsy with Richardson's Syndrome and Variant Phenotypes.
%J Movement disorders
%V 38
%N 10
%@ 0885-3185
%C New York, NY
%I Wiley
%M DZNE-2023-01041
%P 1891 - 1900
%D 2023
%X Brain magnetic resonance imaging (MRI) is used to support the diagnosis of progressive supranuclear palsy (PSP). However, the value of visual descriptive, manual planimetric, automatic volumetric MRI markers and fully automatic categorization is unclear, particularly regarding PSP predominance types other than Richardson's syndrome (RS).To compare different visual reading strategies and automatic classification of T1-weighted MRI for detection of PSP in a typical clinical cohort including PSP-RS and (non-RS) variant PSP (vPSP) patients.Forty-one patients (21 RS, 20 vPSP) and 46 healthy controls were included. Three readers using three strategies performed MRI analysis: exclusively visual reading using descriptive signs (hummingbird, morning-glory, Mickey-Mouse), visual reading supported by manual planimetry measures, and visual reading supported by automatic volumetry. Fully automatic classification was performed using a pre-trained support vector machine (SVM) on the results of atlas-based volumetry.All tested methods achieved higher specificity than sensitivity. Limited sensitivity was driven to large extent by false negative vPSP cases. Support by automatic volumetry resulted in the highest accuracy (75.1
%K Humans
%K Animals
%K Mice
%K Supranuclear Palsy, Progressive: pathology
%K Parkinson Disease: diagnosis
%K Brain: diagnostic imaging
%K Brain: pathology
%K Magnetic Resonance Imaging: methods
%K Mesencephalon: pathology
%K hummingbird sign (Other)
%K machine learning (Other)
%K magnetic resonance imaging (Other)
%K progressive supranuclear palsy (Other)
%K volumetry (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:37545102
%R 10.1002/mds.29527
%U https://pub.dzne.de/record/265797