TY  - JOUR
AU  - Wattjes, Mike P
AU  - Huppertz, Hans-Jürgen
AU  - Mahmoudi, Nima
AU  - Stöcklein, Sophia
AU  - Rogozinski, Sophia
AU  - Wegner, Florian
AU  - Klietz, Martin
AU  - Apostolova, Ivayla
AU  - Levin, Johannes
AU  - Katzdobler, Sabrina
AU  - Buhmann, Carsten
AU  - Quattrone, Andrea
AU  - Berding, Georg
AU  - Brendel, Matthias
AU  - Barthel, Henryk
AU  - Sabri, Osama
AU  - Höglinger, Günter
AU  - Buchert, Ralph
TI  - Brain MRI in Progressive Supranuclear Palsy with Richardson's Syndrome and Variant Phenotypes.
JO  - Movement disorders
VL  - 38
IS  - 10
SN  - 0885-3185
CY  - New York, NY
PB  - Wiley
M1  - DZNE-2023-01041
SP  - 1891 - 1900
PY  - 2023
AB  - Brain magnetic resonance imaging (MRI) is used to support the diagnosis of progressive supranuclear palsy (PSP). However, the value of visual descriptive, manual planimetric, automatic volumetric MRI markers and fully automatic categorization is unclear, particularly regarding PSP predominance types other than Richardson's syndrome (RS).To compare different visual reading strategies and automatic classification of T1-weighted MRI for detection of PSP in a typical clinical cohort including PSP-RS and (non-RS) variant PSP (vPSP) patients.Forty-one patients (21 RS, 20 vPSP) and 46 healthy controls were included. Three readers using three strategies performed MRI analysis: exclusively visual reading using descriptive signs (hummingbird, morning-glory, Mickey-Mouse), visual reading supported by manual planimetry measures, and visual reading supported by automatic volumetry. Fully automatic classification was performed using a pre-trained support vector machine (SVM) on the results of atlas-based volumetry.All tested methods achieved higher specificity than sensitivity. Limited sensitivity was driven to large extent by false negative vPSP cases. Support by automatic volumetry resulted in the highest accuracy (75.1
KW  - Humans
KW  - Animals
KW  - Mice
KW  - Supranuclear Palsy, Progressive: pathology
KW  - Parkinson Disease: diagnosis
KW  - Brain: diagnostic imaging
KW  - Brain: pathology
KW  - Magnetic Resonance Imaging: methods
KW  - Mesencephalon: pathology
KW  - hummingbird sign (Other)
KW  - machine learning (Other)
KW  - magnetic resonance imaging (Other)
KW  - progressive supranuclear palsy (Other)
KW  - volumetry (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:37545102
DO  - DOI:10.1002/mds.29527
UR  - https://pub.dzne.de/record/265797
ER  -