000265939 001__ 265939
000265939 005__ 20240808170117.0
000265939 0247_ $$2doi$$a10.1016/j.cell.2023.10.001
000265939 0247_ $$2pmid$$apmid:37918394
000265939 0247_ $$2ISSN$$a0092-8674
000265939 0247_ $$2ISSN$$a1097-4172
000265939 0247_ $$2altmetric$$aaltmetric:155960108
000265939 037__ $$aDZNE-2023-01062
000265939 041__ $$aEnglish
000265939 082__ $$a610
000265939 1001_ $$0P:(DE-2719)2812526$$aReincke, Momsen$$b0$$eFirst author$$udzne
000265939 245__ $$aChimeric autoantibody receptor T cells deplete NMDA receptor-specific B cells.
000265939 260__ $$aNew York, NY$$bElsevier$$c2023
000265939 3367_ $$2DRIVER$$aarticle
000265939 3367_ $$2DataCite$$aOutput Types/Journal article
000265939 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1700487725_2203
000265939 3367_ $$2BibTeX$$aARTICLE
000265939 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000265939 3367_ $$00$$2EndNote$$aJournal Article
000265939 520__ $$aAnti-NMDA receptor (NMDAR) autoantibodies cause NMDAR encephalitis, the most common autoimmune encephalitis, leading to psychosis, seizures, and autonomic dysfunction. Current treatments comprise broad immunosuppression or non-selective antibody removal. We developed NMDAR-specific chimeric autoantibody receptor (NMDAR-CAAR) T cells to selectively eliminate anti-NMDAR B cells and disease-causing autoantibodies. NMDAR-CAARs consist of an extracellular multi-subunit NMDAR autoantigen fused to intracellular 4-1BB/CD3ζ domains. NMDAR-CAAR T cells recognize a large panel of human patient-derived autoantibodies, release effector molecules, proliferate, and selectively kill antigen-specific target cell lines even in the presence of high autoantibody concentrations. In a passive transfer mouse model, NMDAR-CAAR T cells led to depletion of an anti-NMDAR B cell line and sustained reduction of autoantibody levels without notable off-target toxicity. Treatment of patients may reduce side effects, prevent relapses, and improve long-term prognosis. Our preclinical work paves the way for CAAR T cell phase I/II trials in NMDAR encephalitis and further autoantibody-mediated diseases.
000265939 536__ $$0G:(DE-HGF)POF4-353$$a353 - Clinical and Health Care Research (POF4-353)$$cPOF4-353$$fPOF IV$$x0
000265939 536__ $$0G:(DE-HGF)POF4-351$$a351 - Brain Function (POF4-351)$$cPOF4-351$$fPOF IV$$x1
000265939 588__ $$aDataset connected to CrossRef, PubMed, , Journals: pub.dzne.de
000265939 650_2 $$2MeSH$$aAnimals
000265939 650_2 $$2MeSH$$aHumans
000265939 650_2 $$2MeSH$$aMice
000265939 650_2 $$2MeSH$$aAutoantibodies: metabolism
000265939 650_2 $$2MeSH$$aEncephalitis: metabolism
000265939 650_2 $$2MeSH$$aEncephalitis: therapy
000265939 650_2 $$2MeSH$$aReceptors, N-Methyl-D-Aspartate
000265939 650_2 $$2MeSH$$aT-Lymphocytes
000265939 650_2 $$2MeSH$$aAutoimmune Diseases
000265939 650_2 $$2MeSH$$aDisease Models, Animal
000265939 650_7 $$2Other$$aCAAR T cell
000265939 650_7 $$2Other$$aCAAR T cell
000265939 650_7 $$2Other$$aCAAR T cell
000265939 650_7 $$2Other$$aCAAR T cell
000265939 650_7 $$2Other$$aCAAR T cell
000265939 650_7 $$2Other$$aCAAR T cell
000265939 650_7 $$2Other$$aNMDA receptor encephalitis
000265939 650_7 $$2Other$$aT cells
000265939 650_7 $$2Other$$aautoimmune encephalitis
000265939 650_7 $$2Other$$aautoimmunity
000265939 650_7 $$2Other$$acell therapy
000265939 650_7 $$2Other$$achimeric autoantibody receptor
000265939 650_7 $$2NLM Chemicals$$aAutoantibodies
000265939 650_7 $$2NLM Chemicals$$aReceptors, N-Methyl-D-Aspartate
000265939 693__ $$0EXP:(DE-2719)LAT-20190308$$5EXP:(DE-2719)LAT-20190308$$eLaboratory Automation Technologies (CRFS-LAT) / Bonn$$x0
000265939 7001_ $$0P:(DE-2719)9000805$$avon-Wardenburg, Niels-Oliver$$b1$$udzne
000265939 7001_ $$0P:(DE-2719)9001962$$aHomeyer, Marie Alice$$b2
000265939 7001_ $$0P:(DE-2719)2811900$$aKornau, Hans-Christian$$b3$$udzne
000265939 7001_ $$0P:(DE-2719)9002395$$aSpagni, Gregorio$$b4$$udzne
000265939 7001_ $$0P:(DE-HGF)0$$aLi, Lucie Y$$b5
000265939 7001_ $$0P:(DE-2719)2811468$$aKreye, Jakob$$b6$$udzne
000265939 7001_ $$0P:(DE-2719)2812653$$aSánchez-Sendín, Elisa$$b7$$udzne
000265939 7001_ $$0P:(DE-2719)9002227$$aBlumenau, Sonja$$b8$$udzne
000265939 7001_ $$0P:(DE-2719)2812160$$aStappert, Dominik$$b9$$udzne
000265939 7001_ $$aRadbruch, Helena$$b10
000265939 7001_ $$aHauser, Anja E$$b11
000265939 7001_ $$aKünkele, Annette$$b12
000265939 7001_ $$aEdes, Inan$$b13
000265939 7001_ $$0P:(DE-2719)2810725$$aSchmitz, Dietmar$$b14$$udzne
000265939 7001_ $$0P:(DE-2719)2810931$$aPrüss, Harald$$b15$$eLast author$$udzne
000265939 773__ $$0PERI:(DE-600)2001951-8$$a10.1016/j.cell.2023.10.001$$gVol. 186, no. 23, p. 5084 - 5097.e18$$n23$$p5084 - 5097.e18$$tCell$$v186$$x0092-8674$$y2023
000265939 8564_ $$uhttps://pub.dzne.de/record/265939/files/DZNE-2023-01062.pdf
000265939 8564_ $$uhttps://pub.dzne.de/record/265939/files/DZNE-2023-01062.pdf?subformat=pdfa$$xpdfa
000265939 909CO $$ooai:pub.dzne.de:265939$$pVDB
000265939 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812526$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b0$$kDZNE
000265939 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9000805$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b1$$kDZNE
000265939 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9001962$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b2$$kDZNE
000265939 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811900$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b3$$kDZNE
000265939 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9002395$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b4$$kDZNE
000265939 9101_ $$0I:(DE-588)1065079516$$6P:(DE-HGF)0$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b5$$kDZNE
000265939 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811468$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b6$$kDZNE
000265939 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812653$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b7$$kDZNE
000265939 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)9002227$$aExternal Institute$$b8$$kExtern
000265939 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812160$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b9$$kDZNE
000265939 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2810725$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b14$$kDZNE
000265939 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2810931$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b15$$kDZNE
000265939 9131_ $$0G:(DE-HGF)POF4-353$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vClinical and Health Care Research$$x0
000265939 9131_ $$0G:(DE-HGF)POF4-351$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vBrain Function$$x1
000265939 9141_ $$y2023
000265939 915__ $$0StatID:(DE-HGF)0420$$2StatID$$aNationallizenz$$d2023-10-22$$wger
000265939 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2023-10-22
000265939 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2023-10-22
000265939 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2023-10-22
000265939 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2023-10-22
000265939 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2023-10-22
000265939 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2023-10-22
000265939 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bCELL : 2022$$d2023-10-22
000265939 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2023-10-22
000265939 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2023-10-22
000265939 915__ $$0StatID:(DE-HGF)9960$$2StatID$$aIF >= 60$$bCELL : 2022$$d2023-10-22
000265939 9201_ $$0I:(DE-2719)1810003$$kAG Prüß$$lAutoimmune Encephalopathies$$x0
000265939 9201_ $$0I:(DE-2719)1040190$$kLAT$$lLaboratory Automation Technologies (CRFS-LAT)$$x1
000265939 9201_ $$0I:(DE-2719)1810004$$kAG Schmitz$$lNetwork Dysfunction$$x2
000265939 980__ $$ajournal
000265939 980__ $$aVDB
000265939 980__ $$aI:(DE-2719)1810003
000265939 980__ $$aI:(DE-2719)1040190
000265939 980__ $$aI:(DE-2719)1810004
000265939 980__ $$aUNRESTRICTED