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@ARTICLE{Ltt:265958,
      author       = {Lütt, A. and Tsamitros, N. and Wolbers, T. and Rosenthal,
                      A. and Bröcker, A. L. and Schöneck, R. and Bermpohl, F.
                      and Heinz, A. and Beck, A. and Gutwinski, S.},
      title        = {{A}n explorative single-arm clinical study to assess
                      craving in patients with alcohol use disorder using
                      {V}irtual {R}eality exposure ({CRAVE})-study protocol.},
      journal      = {BMC psychiatry},
      volume       = {23},
      number       = {1},
      issn         = {1471-244X},
      address      = {Heidelberg},
      publisher    = {Springer},
      reportid     = {DZNE-2023-01081},
      pages        = {839},
      year         = {2023},
      abstract     = {Alcohol use disorder (AUD) belongs to the most burdensome
                      clinical disorders worldwide. Current treatment approaches
                      yield unsatisfactory long-term effects with relapse rates up
                      to $85\%.$ Craving for alcohol is a major predictor for
                      relapse and can be intentionally induced via cue exposure in
                      real life as well as in Virtual Reality (VR). The induction
                      and habituation of craving via conditioned cues as well as
                      extinction learning is used in Cue Exposure Therapy (CET), a
                      long-known but rarely used strategy in Cognitive Behavioral
                      Therapy (CBT) of AUD. VR scenarios with alcohol related cues
                      offer several advantages over real life scenarios and are
                      within the focus of current efforts to develop new treatment
                      options. As a first step, we aim to analyze if the VR
                      scenarios elicit a transient change in craving levels and if
                      this is measurable via subjective and psychophysiological
                      parameters.A single-arm clinical study will be conducted
                      including n = 60 patients with AUD. Data on severity of AUD
                      and craving, comorbidities, demographics, side effects and
                      the feeling of presence in VR will be assessed. Patients
                      will use a head-mounted display (HMD) to immerse themselves
                      into three different scenarios (neutral vs. two target
                      situations: a living room and a bar) while heart rate, heart
                      rate variability, pupillometry and electrodermal activity
                      will be measured continuously. Subjective craving levels
                      will be assessed before, during and after the VR
                      session.Results of this study will yield insight into the
                      induction of alcohol craving in VR cue exposure paradigms
                      and its measurement via subjective and psychophysiological
                      parameters. This might be an important step in the
                      development of innovative therapeutic approaches in the
                      treatment of patients with AUD.This study was approved by
                      the Charité-Universitätsmedizin Berlin Institutional
                      Review Board (EA1/190/22, 23.05.2023). It was registered on
                      ClinicalTrials.gov (NCT05861843).},
      keywords     = {Humans / Alcohol Drinking / Alcoholism: therapy /
                      Alcoholism: psychology / Craving / Cues / Recurrence /
                      Virtual Reality / Alcohol Use Disorder (Other) / Craving
                      (Other) / Cue Exposure Therapy (Other) / Electrodermal
                      activity (Other) / Heart rate variability (Other) /
                      Psychophysiological parameters (Other) / Pupillometry
                      (Other) / Virtual Reality (Other)},
      cin          = {AG Wolbers},
      ddc          = {610},
      cid          = {I:(DE-2719)1310002},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pmc          = {pmc:PMC10647047},
      pubmed       = {pmid:37964300},
      doi          = {10.1186/s12888-023-05346-y},
      url          = {https://pub.dzne.de/record/265958},
}