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000266094 0247_ $$2doi$$a10.1016/j.conb.2023.102811
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000266094 037__ $$aDZNE-2023-01095
000266094 041__ $$aEnglish
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000266094 1001_ $$aBlaess, Sandra$$b0
000266094 245__ $$aCell type specificity for circuit output in the midbrain dopaminergic system
000266094 260__ $$aPhiladelphia, Pa.$$bCurrent Biology$$c2023
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000266094 520__ $$aMidbrain dopaminergic neurons are a relatively small group of neurons in the mammalian brain controlling a wide range of behaviors. In recent years, increasingly sophisticated tracing, imaging, transcriptomic, and machine learning approaches have provided substantial insights into the anatomical, molecular, and functional heterogeneity of dopaminergic neurons. Despite this wealth of new knowledge, it remains unclear whether and how the diverse features defining dopaminergic subclasses converge to delineate functional ensembles within the dopaminergic system. Here, we review recent studies investigating various aspects of dopaminergic heterogeneity and discuss how development, behavior, and disease influence subtype characteristics. We then outline what further approaches could be pursued to gain a more inclusive picture of dopaminergic diversity, which could be crucial to understanding the functional architecture of this system.
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000266094 650_2 $$2MeSH$$aAnimals
000266094 650_2 $$2MeSH$$aMesencephalon: metabolism
000266094 650_2 $$2MeSH$$aBrain
000266094 650_2 $$2MeSH$$aDopaminergic Neurons: physiology
000266094 650_2 $$2MeSH$$aMammals
000266094 7001_ $$0P:(DE-2719)9001056$$aKrabbe, Sabine$$b1$$eLast author
000266094 773__ $$0PERI:(DE-600)2013035-1$$a10.1016/j.conb.2023.102811$$gVol. 83, p. 102811 -$$p102811$$tCurrent opinion in neurobiology$$v83$$x0959-4388$$y2023
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