TY  - JOUR
AU  - Blaess, Sandra
AU  - Krabbe, Sabine
TI  - Cell type specificity for circuit output in the midbrain dopaminergic system
JO  - Current opinion in neurobiology
VL  - 83
SN  - 0959-4388
CY  - Philadelphia, Pa.
PB  - Current Biology
M1  - DZNE-2023-01095
SP  - 102811
PY  - 2023
AB  - Midbrain dopaminergic neurons are a relatively small group of neurons in the mammalian brain controlling a wide range of behaviors. In recent years, increasingly sophisticated tracing, imaging, transcriptomic, and machine learning approaches have provided substantial insights into the anatomical, molecular, and functional heterogeneity of dopaminergic neurons. Despite this wealth of new knowledge, it remains unclear whether and how the diverse features defining dopaminergic subclasses converge to delineate functional ensembles within the dopaminergic system. Here, we review recent studies investigating various aspects of dopaminergic heterogeneity and discuss how development, behavior, and disease influence subtype characteristics. We then outline what further approaches could be pursued to gain a more inclusive picture of dopaminergic diversity, which could be crucial to understanding the functional architecture of this system.
KW  - Animals
KW  - Mesencephalon: metabolism
KW  - Brain
KW  - Dopaminergic Neurons: physiology
KW  - Mammals
LB  - PUB:(DE-HGF)16
C6  - pmid:37972537
DO  - DOI:10.1016/j.conb.2023.102811
UR  - https://pub.dzne.de/record/266094
ER  -