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001     266094
005     20240112171210.0
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024 7 _ |a 10.1016/j.conb.2023.102811
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024 7 _ |a 0959-4388
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024 7 _ |a 1873-6882
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037 _ _ |a DZNE-2023-01095
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Blaess, Sandra
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245 _ _ |a Cell type specificity for circuit output in the midbrain dopaminergic system
260 _ _ |a Philadelphia, Pa.
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|b Current Biology
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520 _ _ |a Midbrain dopaminergic neurons are a relatively small group of neurons in the mammalian brain controlling a wide range of behaviors. In recent years, increasingly sophisticated tracing, imaging, transcriptomic, and machine learning approaches have provided substantial insights into the anatomical, molecular, and functional heterogeneity of dopaminergic neurons. Despite this wealth of new knowledge, it remains unclear whether and how the diverse features defining dopaminergic subclasses converge to delineate functional ensembles within the dopaminergic system. Here, we review recent studies investigating various aspects of dopaminergic heterogeneity and discuss how development, behavior, and disease influence subtype characteristics. We then outline what further approaches could be pursued to gain a more inclusive picture of dopaminergic diversity, which could be crucial to understanding the functional architecture of this system.
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650 _ 2 |a Animals
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650 _ 2 |a Mesencephalon: metabolism
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650 _ 2 |a Brain
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650 _ 2 |a Dopaminergic Neurons: physiology
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650 _ 2 |a Mammals
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700 1 _ |a Krabbe, Sabine
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773 _ _ |a 10.1016/j.conb.2023.102811
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|t Current opinion in neurobiology
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856 4 _ |u https://pub.dzne.de/record/266094/files/DZNE-2023-01095.pdf
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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