TY  - JOUR
AU  - Barba, Lorenzo
AU  - Vollmuth, Christoph
AU  - Abu-Rumeileh, Samir
AU  - Halbgebauer, Steffen
AU  - Oeckl, Patrick
AU  - Steinacker, Petra
AU  - Kollikowski, Alexander M
AU  - Schultz, Cara
AU  - Wolf, Judith
AU  - Pham, Mirko
AU  - Schuhmann, Michael K
AU  - Heuschmann, Peter U
AU  - Haeusler, Karl Georg
AU  - Stoll, Guido
AU  - Neugebauer, Hermann
AU  - Otto, Markus
TI  - Serum β-synuclein, neurofilament light chain and glial fibrillary acidic protein as prognostic biomarkers in moderate-to-severe acute ischemic stroke.
JO  - Scientific reports
VL  - 13
IS  - 1
SN  - 2045-2322
CY  - [London]
PB  - Macmillan Publishers Limited, part of Springer Nature
M1  - DZNE-2023-01100
SP  - 20941
PY  - 2023
AB  - We aimed to assess the prognostic value of serum β-synuclein (β-syn), neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) in patients with moderate-to-severe acute ischemic stroke. We measured β-syn, GFAP and NfL in serum samples collected one day after admission in 30 adult patients with moderate-to-severe ischemic stroke due to middle cerebral artery (MCA) occlusion. We tested the associations between biomarker levels and clinical and radiological scores (National Institute of Health Stroke Scale scores, NIHSS, and Alberta Stroke Program Early CT Score, ASPECTS), as well as measures of functional outcome (modified Rankin Scale, mRS). Serum biomarkers were significantly associated with ASPECTS values (β-syn p = 0.0011, GFAP p = 0.0002) but not with NIHSS scores at admission. Patients who received mechanical thrombectomy and intravenous thrombolysis showed lower β-syn (p = 0.029) und NfL concentrations (p = 0.0024) compared to patients who received only mechanical thrombectomy. According to median biomarker levels, patients with high β-syn, NfL or GFAP levels showed, after therapy, lower clinical improvement (i.e., lower 24-h NIHSS change), higher NIHSS scores during hospitalization and higher mRS scores at 3-month follow-up. Elevated serum concentrations of β-syn (p = 0.016), NfL (p = 0.020) or GFAP (p = 0.010) were significantly associated with 3-month mRS of 3-6 vs. 0-2 even after accounting for age, sex and renal function. In patients with moderate-to-severe acute ischemic stroke, serum β-syn, NfL and GFAP levels associated with clinical and radiological scores at different timepoints and were able to predict short- and middle-term clinical outcomes.
KW  - Adult
KW  - Humans
KW  - beta-Synuclein
KW  - Biomarkers
KW  - Glial Fibrillary Acidic Protein
KW  - Infarction, Middle Cerebral Artery
KW  - Intermediate Filaments
KW  - Ischemic Stroke
KW  - Neurofilament Proteins
KW  - Prognosis
KW  - Stroke: therapy
KW  - beta-Synuclein (NLM Chemicals)
KW  - Biomarkers (NLM Chemicals)
KW  - Glial Fibrillary Acidic Protein (NLM Chemicals)
KW  - Neurofilament Proteins (NLM Chemicals)
KW  - GFAP protein, human (NLM Chemicals)
KW  - SNCB protein, human (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C2  - pmc:PMC10684607
C6  - pmid:38017278
DO  - DOI:10.1038/s41598-023-47765-7
UR  - https://pub.dzne.de/record/266099
ER  -