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000266115 1001_ $$0P:(DE-2719)2812499$$aMenden, Kevin$$b0$$eFirst author$$udzne
000266115 245__ $$aA multi-omics dataset for the analysis of frontotemporal dementia genetic subtypes.
000266115 260__ $$aLondon$$bNature Publ. Group$$c2023
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000266115 520__ $$aUnderstanding the molecular mechanisms underlying frontotemporal dementia (FTD) is essential for the development of successful therapies. Systematic studies on human post-mortem brain tissue of patients with genetic subtypes of FTD are currently lacking. The Risk and Modyfing Factors of Frontotemporal Dementia (RiMod-FTD) consortium therefore has generated a multi-omics dataset for genetic subtypes of FTD to identify common and distinct molecular mechanisms disturbed in disease. Here, we present multi-omics datasets generated from the frontal lobe of post-mortem human brain tissue from patients with mutations in MAPT, GRN and C9orf72 and healthy controls. This data resource consists of four datasets generated with different technologies to capture the transcriptome by RNA-seq, small RNA-seq, CAGE-seq, and methylation profiling. We show concrete examples on how to use the resulting data and confirm current knowledge about FTD and identify new processes for further investigation. This extensive multi-omics dataset holds great value to reveal new research avenues for this devastating disease.
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000266115 650_2 $$2MeSH$$aHumans
000266115 650_2 $$2MeSH$$aFrontal Lobe
000266115 650_2 $$2MeSH$$aFrontotemporal Dementia: genetics
000266115 650_2 $$2MeSH$$aMultiomics
000266115 650_2 $$2MeSH$$aMutation
000266115 7001_ $$0P:(DE-2719)2810784$$aFrancescatto, Margherita$$b1
000266115 7001_ $$0P:(DE-2719)2811886$$aNyima, Tenzin$$b2
000266115 7001_ $$0P:(DE-2719)2810837$$aBlauwendraat, Cornelis$$b3
000266115 7001_ $$0P:(DE-2719)2811729$$aDhingra, Ashutosh$$b4$$udzne
000266115 7001_ $$0P:(DE-2719)2810917$$aCastillo Lizardo, Melissa Gissel$$b5$$udzne
000266115 7001_ $$0P:(DE-2719)2811866$$aFernandes, Noémia$$b6$$udzne
000266115 7001_ $$0P:(DE-2719)2812832$$aKaurani, Lalit$$b7$$udzne
000266115 7001_ $$0P:(DE-2719)9001451$$aKronenberg-Versteeg, Deborah$$b8$$udzne
000266115 7001_ $$0P:(DE-2719)2812917$$aAtasu, Burcu$$b9
000266115 7001_ $$0P:(DE-2719)9001460$$aSadikoglou, Eldem$$b10
000266115 7001_ $$0P:(DE-HGF)0$$aBorroni, Barbara$$b11
000266115 7001_ $$0P:(DE-2719)2812129$$aRodriguez-Nieto, Salvador$$b12$$udzne
000266115 7001_ $$0P:(DE-2719)2811198$$aSimon Sanchez, Javier$$b13
000266115 7001_ $$0P:(DE-2719)2000047$$aFischer, Andre$$b14$$udzne
000266115 7001_ $$0P:(DE-HGF)0$$aCraig, David Wesley$$b15
000266115 7001_ $$0P:(DE-2719)2810592$$aNeumann, Manuela$$b16$$udzne
000266115 7001_ $$0P:(DE-2719)2810547$$aBonn, Stefan$$b17$$udzne
000266115 7001_ $$0P:(DE-2719)2810718$$aRizzu, Patrizia$$b18$$udzne
000266115 7001_ $$0P:(DE-2719)2810728$$aHeutink, Peter$$b19
000266115 773__ $$0PERI:(DE-600)2775191-0$$a10.1038/s41597-023-02598-x$$gVol. 10, no. 1, p. 849$$n1$$p849$$tScientific data$$v10$$x2052-4436$$y2023
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