TY  - JOUR
AU  - Menden, Kevin
AU  - Francescatto, Margherita
AU  - Nyima, Tenzin
AU  - Blauwendraat, Cornelis
AU  - Dhingra, Ashutosh
AU  - Castillo Lizardo, Melissa Gissel
AU  - Fernandes, Noémia
AU  - Kaurani, Lalit
AU  - Kronenberg-Versteeg, Deborah
AU  - Atasu, Burcu
AU  - Sadikoglou, Eldem
AU  - Borroni, Barbara
AU  - Rodriguez-Nieto, Salvador
AU  - Simon Sanchez, Javier
AU  - Fischer, Andre
AU  - Craig, David Wesley
AU  - Neumann, Manuela
AU  - Bonn, Stefan
AU  - Rizzu, Patrizia
AU  - Heutink, Peter
TI  - A multi-omics dataset for the analysis of frontotemporal dementia genetic subtypes.
JO  - Scientific data
VL  - 10
IS  - 1
SN  - 2052-4436
CY  - London
PB  - Nature Publ. Group
M1  - DZNE-2023-01109
SP  - 849
PY  - 2023
AB  - Understanding the molecular mechanisms underlying frontotemporal dementia (FTD) is essential for the development of successful therapies. Systematic studies on human post-mortem brain tissue of patients with genetic subtypes of FTD are currently lacking. The Risk and Modyfing Factors of Frontotemporal Dementia (RiMod-FTD) consortium therefore has generated a multi-omics dataset for genetic subtypes of FTD to identify common and distinct molecular mechanisms disturbed in disease. Here, we present multi-omics datasets generated from the frontal lobe of post-mortem human brain tissue from patients with mutations in MAPT, GRN and C9orf72 and healthy controls. This data resource consists of four datasets generated with different technologies to capture the transcriptome by RNA-seq, small RNA-seq, CAGE-seq, and methylation profiling. We show concrete examples on how to use the resulting data and confirm current knowledge about FTD and identify new processes for further investigation. This extensive multi-omics dataset holds great value to reveal new research avenues for this devastating disease.
KW  - Humans
KW  - Frontal Lobe
KW  - Frontotemporal Dementia: genetics
KW  - Multiomics
KW  - Mutation
LB  - PUB:(DE-HGF)16
C6  - pmid:38040703
C2  - pmc:PMC10692098
DO  - DOI:10.1038/s41597-023-02598-x
UR  - https://pub.dzne.de/record/266115
ER  -