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@ARTICLE{Endepols:266481,
      author       = {Endepols, Heike and Anglada-Huguet, Marta and Mandelkow,
                      Eckhard and Neumaier, Bernd and Mandelkow, Eva Maria and
                      Drzezga, Alexander},
      title        = {{F}ragmentation of functional resting state brain networks
                      in a transgenic mouse model of tau pathology: {A} metabolic
                      connectivity study using [18{F}]{FDG}-{PET}},
      journal      = {Experimental neurology},
      volume       = {372},
      issn         = {0014-4886},
      address      = {Orlando, Fla.},
      publisher    = {Academic Press},
      reportid     = {DZNE-2023-01166},
      pages        = {114632},
      year         = {2024},
      abstract     = {In a previous study, regional reductions in cerebral
                      glucose metabolism have been demonstrated in the tauopathy
                      mouse model rTg4510 (Endepols et al., 2022). Notably,
                      glucose hypometabolism was present in some brain regions
                      without co-localized synaptic degeneration measured with
                      [18F]UCB-H. We hypothesized that in those regions
                      hypometabolism may reflect reduced functional connectivity
                      rather than synaptic damage. To test this hypothesis, we
                      performed seed-based metabolic connectivity analyses using
                      [18F]FDG-PET data in this mouse model. Eight rTg4510 mice at
                      the age of seven months and 8 non-transgenic littermates
                      were injected intraperitoneally with 11.1 ± 0.8 MBq
                      [18F]FDG and spent a 35-min uptake period awake in single
                      cages. Subsequently, they were anesthetized and measured in
                      a small animal PET scanner for 30 min. Three seed-based
                      connectivity analyses were performed per group. Seeds were
                      selected for apparent mismatch between [18F]FDG and
                      [18F]UCB-H. A seed was placed either in the medial
                      orbitofrontal cortex, dorsal hippocampus or dorsal thalamus,
                      and correlated with all other voxels of the brain across
                      animals. In the control group, the emerging correlative
                      pattern was strongly overlapping for all three seed
                      locations, indicating a uniform fronto-thalamo-hippocampal
                      resting state network. In contrast, rTg4510 mice showed
                      three distinct networks with minimal overlap. Frontal and
                      thalamic networks were greatly diminished. The hippocampus,
                      however, formed a new network with the whole parietal
                      cortex. We conclude that resting-state functional networks
                      are fragmented in the brain of rTg4510 mice. Thus,
                      hypometabolism can be explained by reduced functional
                      connectivity of brain areas devoid of tau-related pathology,
                      such as the thalamus.},
      keywords     = {Animals / Mice / Fluorodeoxyglucose F18: metabolism / Mice,
                      Transgenic / Positron-Emission Tomography / Brain:
                      metabolism / Brain Mapping / Disease Models, Animal /
                      Magnetic Resonance Imaging / Metabolic connectivity (Other)
                      / Small animal PET (Other) / Tauopathy mouse model (Other) /
                      Fluorodeoxyglucose F18 (NLM Chemicals)},
      cin          = {AG Boecker / AG Schneider / AG Mandelkow 2},
      ddc          = {610},
      cid          = {I:(DE-2719)1011202 / I:(DE-2719)1011305 /
                      I:(DE-2719)1013015},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38052272},
      doi          = {10.1016/j.expneurol.2023.114632},
      url          = {https://pub.dzne.de/record/266481},
}