%0 Journal Article
%A Keil, Julian
%A Kiiski, Hanni
%A Doherty, Liam
%A Hernandez-Urbina, Victor
%A Vassiliou, Chrystalleni
%A Dean, Camin
%A Müschenich, Markus
%A Bahmani, Hamed
%T Artificial sharp-wave-ripples to support memory and counter neurodegeneration.
%J Brain research
%V 1822
%@ 0006-8993
%C Amsterdam
%I Elsevier
%M DZNE-2023-01188
%P 148646
%D 2024
%X Information processed in our sensory neocortical areas is transported to the hippocampus during memory encoding, and between hippocampus and neocortex during memory consolidation, and retrieval. Short bursts of high-frequency oscillations, so called sharp-wave-ripples, have been proposed as a potential mechanism for this information transfer: They can synchronize neural activity to support the formation of local neural networks to store information, and between distant cortical sites to act as a bridge to transfer information between sensory cortical areas and hippocampus. In neurodegenerative diseases like Alzheimer's Disease, different neuropathological processes impair normal neural functioning and neural synchronization as well as sharp-wave-ripples, which impairs consolidation and retrieval of information, and compromises memory. Here, we formulate a new hypothesis, that artificially inducing sharp-wave-ripples with noninvasive high-frequency visual stimulation could potentially support memory functioning, as well as target the neuropathological processes underlying neurodegenerative diseases. We also outline key challenges for empirical tests of the hypothesis.
%K Humans
%K Hippocampus: physiology
%K Neocortex: physiology
%K Parietal Lobe
%K Memory Consolidation: physiology
%K Alzheimer Disease
%K Alzheimer (Other)
%K Gamma (Other)
%K High-Frequency (Other)
%K Hippocampus (Other)
%K Neocortex (Other)
%K Oscillation (Other)
%K Ripple (Other)
%K Theta (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:37871674
%R 10.1016/j.brainres.2023.148646
%U https://pub.dzne.de/record/266503