TY  - JOUR
AU  - Keil, Julian
AU  - Kiiski, Hanni
AU  - Doherty, Liam
AU  - Hernandez-Urbina, Victor
AU  - Vassiliou, Chrystalleni
AU  - Dean, Camin
AU  - Müschenich, Markus
AU  - Bahmani, Hamed
TI  - Artificial sharp-wave-ripples to support memory and counter neurodegeneration.
JO  - Brain research
VL  - 1822
SN  - 0006-8993
CY  - Amsterdam
PB  - Elsevier
M1  - DZNE-2023-01188
SP  - 148646
PY  - 2024
AB  - Information processed in our sensory neocortical areas is transported to the hippocampus during memory encoding, and between hippocampus and neocortex during memory consolidation, and retrieval. Short bursts of high-frequency oscillations, so called sharp-wave-ripples, have been proposed as a potential mechanism for this information transfer: They can synchronize neural activity to support the formation of local neural networks to store information, and between distant cortical sites to act as a bridge to transfer information between sensory cortical areas and hippocampus. In neurodegenerative diseases like Alzheimer's Disease, different neuropathological processes impair normal neural functioning and neural synchronization as well as sharp-wave-ripples, which impairs consolidation and retrieval of information, and compromises memory. Here, we formulate a new hypothesis, that artificially inducing sharp-wave-ripples with noninvasive high-frequency visual stimulation could potentially support memory functioning, as well as target the neuropathological processes underlying neurodegenerative diseases. We also outline key challenges for empirical tests of the hypothesis.
KW  - Humans
KW  - Hippocampus: physiology
KW  - Neocortex: physiology
KW  - Parietal Lobe
KW  - Memory Consolidation: physiology
KW  - Alzheimer Disease
KW  - Alzheimer (Other)
KW  - Gamma (Other)
KW  - High-Frequency (Other)
KW  - Hippocampus (Other)
KW  - Neocortex (Other)
KW  - Oscillation (Other)
KW  - Ripple (Other)
KW  - Theta (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:37871674
DO  - DOI:10.1016/j.brainres.2023.148646
UR  - https://pub.dzne.de/record/266503
ER  -