Home > Publications Database > Artificial sharp-wave-ripples to support memory and counter neurodegeneration. > print

001     266503
005     20240114002129.0
024 7 _ |a 10.1016/j.brainres.2023.148646
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037 _ _ |a DZNE-2023-01188
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Keil, Julian
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245 _ _ |a Artificial sharp-wave-ripples to support memory and counter neurodegeneration.
260 _ _ |a Amsterdam
|c 2024
|b Elsevier
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520 _ _ |a Information processed in our sensory neocortical areas is transported to the hippocampus during memory encoding, and between hippocampus and neocortex during memory consolidation, and retrieval. Short bursts of high-frequency oscillations, so called sharp-wave-ripples, have been proposed as a potential mechanism for this information transfer: They can synchronize neural activity to support the formation of local neural networks to store information, and between distant cortical sites to act as a bridge to transfer information between sensory cortical areas and hippocampus. In neurodegenerative diseases like Alzheimer's Disease, different neuropathological processes impair normal neural functioning and neural synchronization as well as sharp-wave-ripples, which impairs consolidation and retrieval of information, and compromises memory. Here, we formulate a new hypothesis, that artificially inducing sharp-wave-ripples with noninvasive high-frequency visual stimulation could potentially support memory functioning, as well as target the neuropathological processes underlying neurodegenerative diseases. We also outline key challenges for empirical tests of the hypothesis.
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650 _ 7 |a Alzheimer
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650 _ 7 |a Gamma
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650 _ 7 |a High-Frequency
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650 _ 7 |a Hippocampus
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650 _ 7 |a Neocortex
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650 _ 7 |a Oscillation
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650 _ 7 |a Ripple
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650 _ 7 |a Theta
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650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Hippocampus: physiology
|2 MeSH
650 _ 2 |a Neocortex: physiology
|2 MeSH
650 _ 2 |a Parietal Lobe
|2 MeSH
650 _ 2 |a Memory Consolidation: physiology
|2 MeSH
650 _ 2 |a Alzheimer Disease
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700 1 _ |a Kiiski, Hanni
|b 1
700 1 _ |a Doherty, Liam
|b 2
700 1 _ |a Hernandez-Urbina, Victor
|b 3
700 1 _ |a Vassiliou, Chrystalleni
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700 1 _ |a Dean, Camin
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700 1 _ |a Müschenich, Markus
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700 1 _ |a Bahmani, Hamed
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773 _ _ |a 10.1016/j.brainres.2023.148646
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856 4 _ |y OpenAccess
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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