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000266748 1001_ $$00000-0002-8120-2223$$aSollmann, Nico$$b0
000266748 245__ $$aArterial Spin Labeling (ASL) in der neuroradiologischen Diagnostik – Methodischer Überblick und Anwendungsfälle.
000266748 260__ $$aStuttgart [u.a.]$$bThieme$$c2024
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000266748 520__ $$a Arterial spin labeling (ASL) is a magnetic resonance imaging (MRI)-based technique using labeled blood-water of the brain-feeding arteries as an endogenous tracer to derive information about brain perfusion. It enables the assessment of cerebral blood flow (CBF).This review aims to provide a methodological and technical overview of ASL techniques, and to give examples of clinical use cases for various diseases affecting the central nervous system (CNS). There is a special focus on recent developments including super-selective ASL (ssASL) and time-resolved ASL-based magnetic resonance angiography (MRA) and on diseases commonly not leading to characteristic alterations on conventional structural MRI (e. g., concussion or migraine).ASL-derived CBF may represent a clinically relevant parameter in various pathologies such as cerebrovascular diseases, neoplasms, or neurodegenerative diseases. Furthermore, ASL has also been used to investigate CBF in mild traumatic brain injury or migraine, potentially leading to the establishment of imaging-based biomarkers. Recent advances made possible the acquisition of ssASL by selective labeling of single brain-feeding arteries, enabling spatial perfusion territory mapping dependent on blood flow of a specific preselected artery. Furthermore, ASL-based MRA has been introduced, providing time-resolved delineation of single intracranial vessels.Perfusion imaging by ASL has shown promise in various diseases of the CNS. Given that ASL does not require intravenous administration of a gadolinium-based contrast agent, it may be of particular interest for investigations in pediatric cohorts, patients with impaired kidney function, patients with relevant allergies, or patients that undergo serial MRI for clinical indications such as disease monitoring.· ASL is an MRI technique that uses labeled blood-water as an endogenous tracer for brain perfusion imaging.. · It allows the assessment of CBF without the need for administration of a gadolinium-based contrast agent.. · CBF quantification by ASL has been used in several pathologies including brain tumors or neurodegenerative diseases.. · Vessel-selective ASL methods can provide brain perfusion territory mapping in cerebrovascular diseases.. · ASL may be of particular interest in patient cohorts with caveats concerning gadolinium administration..
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000266748 650_7 $$2NLM Chemicals$$aContrast Media
000266748 650_7 $$2NLM Chemicals$$aSpin Labels
000266748 650_7 $$0AU0V1LM3JT$$2NLM Chemicals$$aGadolinium
000266748 650_7 $$0059QF0KO0R$$2NLM Chemicals$$aWater
000266748 650_2 $$2MeSH$$aHumans
000266748 650_2 $$2MeSH$$aChild
000266748 650_2 $$2MeSH$$aContrast Media
000266748 650_2 $$2MeSH$$aSpin Labels
000266748 650_2 $$2MeSH$$aGadolinium
000266748 650_2 $$2MeSH$$aMagnetic Resonance Imaging: methods
000266748 650_2 $$2MeSH$$aArteries
000266748 650_2 $$2MeSH$$aMagnetic Resonance Angiography: methods
000266748 650_2 $$2MeSH$$aCerebrovascular Disorders: diagnostic imaging
000266748 650_2 $$2MeSH$$aMigraine Disorders
000266748 650_2 $$2MeSH$$aWater
000266748 650_2 $$2MeSH$$aNeurodegenerative Diseases
000266748 7001_ $$aHoffmann, Gabriel$$b1
000266748 7001_ $$aSchramm, Severin$$b2
000266748 7001_ $$aReichert, Miriam$$b3
000266748 7001_ $$aHernandez Petzsche, Moritz$$b4
000266748 7001_ $$aStrobel, Joachim$$b5
000266748 7001_ $$aNigris, Lorenzo$$b6
000266748 7001_ $$aKloth, Christopher$$b7
000266748 7001_ $$00000-0002-9037-5660$$aRosskopf, Johannes$$b8
000266748 7001_ $$aBörner, Corinna$$b9
000266748 7001_ $$aBonfert, Michaela$$b10
000266748 7001_ $$aBerndt, Maria$$b11
000266748 7001_ $$aGrön, Georg$$b12
000266748 7001_ $$aMüller, Hans-Peter$$b13
000266748 7001_ $$0P:(DE-2719)9001967$$aKassubek, Jan$$b14$$udzne
000266748 7001_ $$aKreiser, Kornelia$$b15
000266748 7001_ $$aKoerte, Inga K$$b16
000266748 7001_ $$aLiebl, Hans$$b17
000266748 7001_ $$aBeer, Ambros$$b18
000266748 7001_ $$aZimmer, Claus$$b19
000266748 7001_ $$aBeer, Meinrad$$b20
000266748 7001_ $$aKaczmarz, Stephan$$b21
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