TY  - JOUR
AU  - Sollmann, Nico
AU  - Hoffmann, Gabriel
AU  - Schramm, Severin
AU  - Reichert, Miriam
AU  - Hernandez Petzsche, Moritz
AU  - Strobel, Joachim
AU  - Nigris, Lorenzo
AU  - Kloth, Christopher
AU  - Rosskopf, Johannes
AU  - Börner, Corinna
AU  - Bonfert, Michaela
AU  - Berndt, Maria
AU  - Grön, Georg
AU  - Müller, Hans-Peter
AU  - Kassubek, Jan
AU  - Kreiser, Kornelia
AU  - Koerte, Inga K
AU  - Liebl, Hans
AU  - Beer, Ambros
AU  - Zimmer, Claus
AU  - Beer, Meinrad
AU  - Kaczmarz, Stephan
TI  - Arterial Spin Labeling (ASL) in der neuroradiologischen Diagnostik – Methodischer Überblick und Anwendungsfälle.
JO  - RöFo
VL  - 196
IS  - 1
SN  - 0367-2239
CY  - Stuttgart [u.a.]
PB  - Thieme
M1  - DZNE-2024-00011
SP  - 36 - 51
PY  - 2024
AB  -  Arterial spin labeling (ASL) is a magnetic resonance imaging (MRI)-based technique using labeled blood-water of the brain-feeding arteries as an endogenous tracer to derive information about brain perfusion. It enables the assessment of cerebral blood flow (CBF).This review aims to provide a methodological and technical overview of ASL techniques, and to give examples of clinical use cases for various diseases affecting the central nervous system (CNS). There is a special focus on recent developments including super-selective ASL (ssASL) and time-resolved ASL-based magnetic resonance angiography (MRA) and on diseases commonly not leading to characteristic alterations on conventional structural MRI (e. g., concussion or migraine).ASL-derived CBF may represent a clinically relevant parameter in various pathologies such as cerebrovascular diseases, neoplasms, or neurodegenerative diseases. Furthermore, ASL has also been used to investigate CBF in mild traumatic brain injury or migraine, potentially leading to the establishment of imaging-based biomarkers. Recent advances made possible the acquisition of ssASL by selective labeling of single brain-feeding arteries, enabling spatial perfusion territory mapping dependent on blood flow of a specific preselected artery. Furthermore, ASL-based MRA has been introduced, providing time-resolved delineation of single intracranial vessels.Perfusion imaging by ASL has shown promise in various diseases of the CNS. Given that ASL does not require intravenous administration of a gadolinium-based contrast agent, it may be of particular interest for investigations in pediatric cohorts, patients with impaired kidney function, patients with relevant allergies, or patients that undergo serial MRI for clinical indications such as disease monitoring.· ASL is an MRI technique that uses labeled blood-water as an endogenous tracer for brain perfusion imaging.. · It allows the assessment of CBF without the need for administration of a gadolinium-based contrast agent.. · CBF quantification by ASL has been used in several pathologies including brain tumors or neurodegenerative diseases.. · Vessel-selective ASL methods can provide brain perfusion territory mapping in cerebrovascular diseases.. · ASL may be of particular interest in patient cohorts with caveats concerning gadolinium administration..
KW  - Humans
KW  - Child
KW  - Contrast Media
KW  - Spin Labels
KW  - Gadolinium
KW  - Magnetic Resonance Imaging: methods
KW  - Arteries
KW  - Magnetic Resonance Angiography: methods
KW  - Cerebrovascular Disorders: diagnostic imaging
KW  - Migraine Disorders
KW  - Water
KW  - Neurodegenerative Diseases
KW  - Contrast Media (NLM Chemicals)
KW  - Spin Labels (NLM Chemicals)
KW  - Gadolinium (NLM Chemicals)
KW  - Water (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:37467779
DO  - DOI:10.1055/a-2119-5574
UR  - https://pub.dzne.de/record/266748
ER  -