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@ARTICLE{Sollmann:266748,
      author       = {Sollmann, Nico and Hoffmann, Gabriel and Schramm, Severin
                      and Reichert, Miriam and Hernandez Petzsche, Moritz and
                      Strobel, Joachim and Nigris, Lorenzo and Kloth, Christopher
                      and Rosskopf, Johannes and Börner, Corinna and Bonfert,
                      Michaela and Berndt, Maria and Grön, Georg and Müller,
                      Hans-Peter and Kassubek, Jan and Kreiser, Kornelia and
                      Koerte, Inga K and Liebl, Hans and Beer, Ambros and Zimmer,
                      Claus and Beer, Meinrad and Kaczmarz, Stephan},
      title        = {{A}rterial {S}pin {L}abeling ({ASL}) in der
                      neuroradiologischen {D}iagnostik – {M}ethodischer
                      Überblick und {A}nwendungsfälle.},
      journal      = {RöFo},
      volume       = {196},
      number       = {1},
      issn         = {0367-2239},
      address      = {Stuttgart [u.a.]},
      publisher    = {Thieme},
      reportid     = {DZNE-2024-00011},
      pages        = {36 - 51},
      year         = {2024},
      abstract     = {Arterial spin labeling (ASL) is a magnetic resonance
                      imaging (MRI)-based technique using labeled blood-water of
                      the brain-feeding arteries as an endogenous tracer to derive
                      information about brain perfusion. It enables the assessment
                      of cerebral blood flow (CBF).This review aims to provide a
                      methodological and technical overview of ASL techniques, and
                      to give examples of clinical use cases for various diseases
                      affecting the central nervous system (CNS). There is a
                      special focus on recent developments including
                      super-selective ASL (ssASL) and time-resolved ASL-based
                      magnetic resonance angiography (MRA) and on diseases
                      commonly not leading to characteristic alterations on
                      conventional structural MRI (e. g., concussion or
                      migraine).ASL-derived CBF may represent a clinically
                      relevant parameter in various pathologies such as
                      cerebrovascular diseases, neoplasms, or neurodegenerative
                      diseases. Furthermore, ASL has also been used to investigate
                      CBF in mild traumatic brain injury or migraine, potentially
                      leading to the establishment of imaging-based biomarkers.
                      Recent advances made possible the acquisition of ssASL by
                      selective labeling of single brain-feeding arteries,
                      enabling spatial perfusion territory mapping dependent on
                      blood flow of a specific preselected artery. Furthermore,
                      ASL-based MRA has been introduced, providing time-resolved
                      delineation of single intracranial vessels.Perfusion imaging
                      by ASL has shown promise in various diseases of the CNS.
                      Given that ASL does not require intravenous administration
                      of a gadolinium-based contrast agent, it may be of
                      particular interest for investigations in pediatric cohorts,
                      patients with impaired kidney function, patients with
                      relevant allergies, or patients that undergo serial MRI for
                      clinical indications such as disease monitoring.· ASL is an
                      MRI technique that uses labeled blood-water as an endogenous
                      tracer for brain perfusion imaging.. · It allows the
                      assessment of CBF without the need for administration of a
                      gadolinium-based contrast agent.. · CBF quantification by
                      ASL has been used in several pathologies including brain
                      tumors or neurodegenerative diseases.. · Vessel-selective
                      ASL methods can provide brain perfusion territory mapping in
                      cerebrovascular diseases.. · ASL may be of particular
                      interest in patient cohorts with caveats concerning
                      gadolinium administration..},
      subtyp        = {Review Article},
      keywords     = {Humans / Child / Contrast Media / Spin Labels / Gadolinium
                      / Magnetic Resonance Imaging: methods / Arteries / Magnetic
                      Resonance Angiography: methods / Cerebrovascular Disorders:
                      diagnostic imaging / Migraine Disorders / Water /
                      Neurodegenerative Diseases / Contrast Media (NLM Chemicals)
                      / Spin Labels (NLM Chemicals) / Gadolinium (NLM Chemicals) /
                      Water (NLM Chemicals)},
      cin          = {Clinical Study Center Ulm},
      ddc          = {610},
      cid          = {I:(DE-2719)5000077},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37467779},
      doi          = {10.1055/a-2119-5574},
      url          = {https://pub.dzne.de/record/266748},
}