TY  - JOUR
AU  - Filler, Jule
AU  - Georgakis, Marios K
AU  - Dichgans, Martin
TI  - Risk factors for cognitive impairment and dementia after stroke: a systematic review and meta-analysis.
JO  - The lancet / Healthy longevity
VL  - 5
IS  - 1
SN  - 2666-7568
CY  - London
PB  - Elsevier
M1  - DZNE-2024-00041
SP  - e31 - e44
PY  - 2024
AB  - Cognitive impairment and dementia are highly prevalent among stroke survivors and represent a major burden for patients, carers, and health-care systems. We studied the risk factors for post-stroke cognitive impairment (PSCI) and dementia (PSD) beyond the well established risk factors of age and stroke severity.In this systematic review and meta-analysis we conducted a systematic literature search from database inception until Sept 15, 2023. We selected prospective and retrospective cohort studies, post-hoc analyses from randomised controlled trials, and nested case-control studies of patients with acute stroke (ischaemic, haemorrhagic, and transient ischaemic attack), exploring associations between risk factors at baseline and PSCI or PSD over a follow-up period of at least 3 months. Study quality was assessed using the Newcastle-Ottawa quality assessment scale. We calculated pooled relative risks (RRs) with random-effects meta-analyses and performed subgroup, meta-regression, and sensitivity analyses. This study was preregistered with PROSPERO, CRD42020164959.We identified 162 eligible articles for our systematic review, of which 113 articles (89 studies, 160 783 patients) were eligible for meta-analysis. Baseline cognitive impairment was the strongest risk factor for PSCI (RR 2·00, 95
KW  - Humans
KW  - Brain Ischemia: complications
KW  - Brain Ischemia: psychology
KW  - Prospective Studies
KW  - Retrospective Studies
KW  - Atrial Fibrillation: complications
KW  - Stroke: complications
KW  - Stroke: epidemiology
KW  - Cognitive Dysfunction: etiology
KW  - Cognitive Dysfunction: complications
KW  - Risk Factors
KW  - Dementia: epidemiology
KW  - Dementia: etiology
KW  - Diabetes Mellitus
LB  - PUB:(DE-HGF)16
C6  - pmid:38101426
DO  - DOI:10.1016/S2666-7568(23)00217-9
UR  - https://pub.dzne.de/record/266783
ER  -