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000266784 037__ $$aDZNE-2024-00042
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000266784 1001_ $$00000-0002-6703-7997$$aKardell, Oliver$$b0
000266784 245__ $$aMulticenter Collaborative Study to Optimize Mass Spectrometry Workflows of Clinical Specimens.
000266784 260__ $$aWashington, DC$$bACS Publications$$c2024
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000266784 520__ $$aThe foundation for integrating mass spectrometry (MS)-based proteomics into systems medicine is the development of standardized start-to-finish and fit-for-purpose workflows for clinical specimens. An essential step in this pursuit is to highlight the common ground in a diverse landscape of different sample preparation techniques and liquid chromatography-mass spectrometry (LC-MS) setups. With the aim to benchmark and improve the current best practices among the proteomics MS laboratories of the CLINSPECT-M consortium, we performed two consecutive round-robin studies with full freedom to operate in terms of sample preparation and MS measurements. The six study partners were provided with two clinically relevant sample matrices: plasma and cerebrospinal fluid (CSF). In the first round, each laboratory applied their current best practice protocol for the respective matrix. Based on the achieved results and following a transparent exchange of all lab-specific protocols within the consortium, each laboratory could advance their methods before measuring the same samples in the second acquisition round. Both time points are compared with respect to identifications (IDs), data completeness, and precision, as well as reproducibility. As a result, the individual performances of participating study centers were improved in the second measurement, emphasizing the effect and importance of the expert-driven exchange of best practices for direct practical improvements.
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000266784 650_2 $$2MeSH$$aTandem Mass Spectrometry: methods
000266784 650_2 $$2MeSH$$aChromatography, Liquid: methods
000266784 650_2 $$2MeSH$$aWorkflow
000266784 650_2 $$2MeSH$$aReproducibility of Results
000266784 650_2 $$2MeSH$$aPlasma: chemistry
000266784 650_7 $$2Other$$aLC–MS
000266784 650_7 $$2Other$$aLC–MS
000266784 650_7 $$2Other$$aLC–MS
000266784 650_7 $$2Other$$aCSF
000266784 650_7 $$2Other$$aLC–MS
000266784 650_7 $$2Other$$aR package mpwR
000266784 650_7 $$2Other$$aclinical specimen
000266784 650_7 $$2Other$$adata-dependent acquisition
000266784 650_7 $$2Other$$adata-independent acquisition
000266784 650_7 $$2Other$$ainterlaboratory
000266784 650_7 $$2Other$$aintralaboratory
000266784 650_7 $$2Other$$amass spectrometry
000266784 650_7 $$2Other$$aplasma
000266784 650_7 $$2Other$$around-robin study
000266784 7001_ $$avon Toerne, Christine$$b1
000266784 7001_ $$aMerl-Pham, Juliane$$b2
000266784 7001_ $$aKönig, Ann-Christine$$b3
000266784 7001_ $$aBlindert, Marcel$$b4
000266784 7001_ $$aBarth, Teresa K$$b5
000266784 7001_ $$aMergner, Julia$$b6
000266784 7001_ $$00000-0002-6131-7322$$aLudwig, Christina$$b7
000266784 7001_ $$0P:(DE-2719)2812852$$aTüshaus, Johanna$$b8$$udzne
000266784 7001_ $$aEckert, Stephan$$b9
000266784 7001_ $$0P:(DE-2719)2810938$$aMüller, Stephan A$$b10$$udzne
000266784 7001_ $$0P:(DE-2719)9001161$$aBreimann, Stephan$$b11$$udzne
000266784 7001_ $$0P:(DE-2719)9001718$$aGiesbertz, Pieter$$b12$$udzne
000266784 7001_ $$0P:(DE-2719)9002620$$aBernhardt, Alexander Maximilian$$b13$$udzne
000266784 7001_ $$aSchweizer, Lisa$$b14
000266784 7001_ $$aAlbrecht, Vincent$$b15
000266784 7001_ $$aTeupser, Daniel$$b16
000266784 7001_ $$00000-0003-2993-8249$$aImhof, Axel$$b17
000266784 7001_ $$00000-0002-9094-1677$$aKuster, Bernhard$$b18
000266784 7001_ $$0P:(DE-2719)2181459$$aLichtenthaler, Stefan F$$b19$$udzne
000266784 7001_ $$aMann, Matthias$$b20
000266784 7001_ $$00000-0001-8597-205X$$aCox, Jürgen$$b21
000266784 7001_ $$00000-0002-1630-6827$$aHauck, Stefanie M$$b22
000266784 773__ $$0PERI:(DE-600)2065254-9$$a10.1021/acs.jproteome.3c00473$$gVol. 23, no. 1, p. 117 - 129$$n1$$p117 - 129$$tJournal of proteome research$$v23$$x1535-3893$$y2024
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