%0 Journal Article
%A Erhart, Deborah Katharina
%A Klose, Veronika
%A Schäper, Tatjana
%A Tumani, Hayrettin
%A Senel, Makbule
%T CXCL13 in Cerebrospinal Fluid: Clinical Value in a Large Cross-Sectional Study.
%J International journal of molecular sciences
%V 25
%N 1
%@ 1422-0067
%C Basel
%I Molecular Diversity Preservation International
%M DZNE-2024-00056
%P 425
%D 2023
%X C-X-C-motif chemokine ligand 13 (CXCL13) in cerebrospinal fluid (CSF) is increasingly used in clinical routines, although its diagnostic specificity and divergent cut-off values have been defined so far mainly for neuroborreliosis. Our aim was to evaluate the value of CSF-CXCL13 as a diagnostic and treatment response marker and its role as an activity marker in a larger disease spectrum, including neuroborreliosis and other neuroinflammatory and malignant CNS-disorders. Patients who received a diagnostic lumbar puncture (LP) (n = 1234) between July 2009 and January 2023 were included in our retrospective cross-sectional study. The diagnostic performance of CSF-CXCL13 for acute neuroborreliosis was highest at a cut-off of 428.92 pg/mL (sensitivity: 92.1
%K Humans
%K Cross-Sectional Studies
%K Retrospective Studies
%K Spinal Puncture
%K Multiple Sclerosis
%K Neurosyphilis
%K Syndrome
%K Chemokine CXCL13
%K CXCL13 protein, human (NLM Chemicals)
%K CNS-inflammatory diseases (Other)
%K CXCL13 (Other)
%K cerebrospinal fluid (Other)
%K neuroborreliosis (Other)
%K Chemokine CXCL13 (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%2 pmc:PMC10779058
%$ pmid:38203597
%R 10.3390/ijms25010425
%U https://pub.dzne.de/record/266804