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000266804 037__ $$aDZNE-2024-00056
000266804 041__ $$aEnglish
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000266804 1001_ $$00000-0002-3003-4119$$aErhart, Deborah Katharina$$b0
000266804 245__ $$aCXCL13 in Cerebrospinal Fluid: Clinical Value in a Large Cross-Sectional Study.
000266804 260__ $$aBasel$$bMolecular Diversity Preservation International$$c2023
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000266804 520__ $$aC-X-C-motif chemokine ligand 13 (CXCL13) in cerebrospinal fluid (CSF) is increasingly used in clinical routines, although its diagnostic specificity and divergent cut-off values have been defined so far mainly for neuroborreliosis. Our aim was to evaluate the value of CSF-CXCL13 as a diagnostic and treatment response marker and its role as an activity marker in a larger disease spectrum, including neuroborreliosis and other neuroinflammatory and malignant CNS-disorders. Patients who received a diagnostic lumbar puncture (LP) (n = 1234) between July 2009 and January 2023 were included in our retrospective cross-sectional study. The diagnostic performance of CSF-CXCL13 for acute neuroborreliosis was highest at a cut-off of 428.92 pg/mL (sensitivity: 92.1%; specificity: 96.5%). In addition, CXCL13 levels in CSF were significantly elevated in multiple sclerosis with clinical (p = 0.001) and radiographic disease activity (p < 0.001). The clinical utility of CSF-CXCL13 appears to be multifaceted. CSF-CXCL13 is significantly elevated in patients with neuroborreliosis and shows a rapid and sharp decline with antibiotic therapy, but it is not specific for this disease and is also highly elevated in less common subacute neuroinfectious diseases, such as neurosyphilis and cryptococcal meningitis or in primary/secondary B-cell lymphoma.
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000266804 650_7 $$2NLM Chemicals$$aCXCL13 protein, human
000266804 650_7 $$2Other$$aCNS-inflammatory diseases
000266804 650_7 $$2Other$$aCXCL13
000266804 650_7 $$2Other$$acerebrospinal fluid
000266804 650_7 $$2Other$$aneuroborreliosis
000266804 650_7 $$2NLM Chemicals$$aChemokine CXCL13
000266804 650_2 $$2MeSH$$aHumans
000266804 650_2 $$2MeSH$$aCross-Sectional Studies
000266804 650_2 $$2MeSH$$aRetrospective Studies
000266804 650_2 $$2MeSH$$aSpinal Puncture
000266804 650_2 $$2MeSH$$aMultiple Sclerosis
000266804 650_2 $$2MeSH$$aNeurosyphilis
000266804 650_2 $$2MeSH$$aSyndrome
000266804 650_2 $$2MeSH$$aChemokine CXCL13
000266804 7001_ $$0P:(DE-2719)9001084$$aKlose, Veronika$$b1
000266804 7001_ $$aSchäper, Tatjana$$b2
000266804 7001_ $$0P:(DE-2719)9002007$$aTumani, Hayrettin$$b3$$udzne
000266804 7001_ $$00000-0002-2737-7495$$aSenel, Makbule$$b4
000266804 770__ $$aExploring Molecular Mechanisms of Inflammatory Diseases
000266804 773__ $$0PERI:(DE-600)2019364-6$$a10.3390/ijms25010425$$gVol. 25, no. 1, p. 425 -$$n1$$p425$$tInternational journal of molecular sciences$$v25$$x1422-0067$$y2023
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