TY  - JOUR
AU  - Erhart, Deborah Katharina
AU  - Klose, Veronika
AU  - Schäper, Tatjana
AU  - Tumani, Hayrettin
AU  - Senel, Makbule
TI  - CXCL13 in Cerebrospinal Fluid: Clinical Value in a Large Cross-Sectional Study.
JO  - International journal of molecular sciences
VL  - 25
IS  - 1
SN  - 1422-0067
CY  - Basel
PB  - Molecular Diversity Preservation International
M1  - DZNE-2024-00056
SP  - 425
PY  - 2023
AB  - C-X-C-motif chemokine ligand 13 (CXCL13) in cerebrospinal fluid (CSF) is increasingly used in clinical routines, although its diagnostic specificity and divergent cut-off values have been defined so far mainly for neuroborreliosis. Our aim was to evaluate the value of CSF-CXCL13 as a diagnostic and treatment response marker and its role as an activity marker in a larger disease spectrum, including neuroborreliosis and other neuroinflammatory and malignant CNS-disorders. Patients who received a diagnostic lumbar puncture (LP) (n = 1234) between July 2009 and January 2023 were included in our retrospective cross-sectional study. The diagnostic performance of CSF-CXCL13 for acute neuroborreliosis was highest at a cut-off of 428.92 pg/mL (sensitivity: 92.1
KW  - Humans
KW  - Cross-Sectional Studies
KW  - Retrospective Studies
KW  - Spinal Puncture
KW  - Multiple Sclerosis
KW  - Neurosyphilis
KW  - Syndrome
KW  - Chemokine CXCL13
KW  - CXCL13 protein, human (NLM Chemicals)
KW  - CNS-inflammatory diseases (Other)
KW  - CXCL13 (Other)
KW  - cerebrospinal fluid (Other)
KW  - neuroborreliosis (Other)
KW  - Chemokine CXCL13 (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C2  - pmc:PMC10779058
C6  - pmid:38203597
DO  - DOI:10.3390/ijms25010425
UR  - https://pub.dzne.de/record/266804
ER  -