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@ARTICLE{Erhart:266804,
      author       = {Erhart, Deborah Katharina and Klose, Veronika and Schäper,
                      Tatjana and Tumani, Hayrettin and Senel, Makbule},
      title        = {{CXCL}13 in {C}erebrospinal {F}luid: {C}linical {V}alue in
                      a {L}arge {C}ross-{S}ectional {S}tudy.},
      journal      = {International journal of molecular sciences},
      volume       = {25},
      number       = {1},
      issn         = {1422-0067},
      address      = {Basel},
      publisher    = {Molecular Diversity Preservation International},
      reportid     = {DZNE-2024-00056},
      pages        = {425},
      year         = {2023},
      abstract     = {C-X-C-motif chemokine ligand 13 (CXCL13) in cerebrospinal
                      fluid (CSF) is increasingly used in clinical routines,
                      although its diagnostic specificity and divergent cut-off
                      values have been defined so far mainly for neuroborreliosis.
                      Our aim was to evaluate the value of CSF-CXCL13 as a
                      diagnostic and treatment response marker and its role as an
                      activity marker in a larger disease spectrum, including
                      neuroborreliosis and other neuroinflammatory and malignant
                      CNS-disorders. Patients who received a diagnostic lumbar
                      puncture (LP) (n = 1234) between July 2009 and January 2023
                      were included in our retrospective cross-sectional study.
                      The diagnostic performance of CSF-CXCL13 for acute
                      neuroborreliosis was highest at a cut-off of 428.92 pg/mL
                      (sensitivity: $92.1\%;$ specificity: $96.5\%).$ In addition,
                      CXCL13 levels in CSF were significantly elevated in multiple
                      sclerosis with clinical (p = 0.001) and radiographic disease
                      activity (p < 0.001). The clinical utility of CSF-CXCL13
                      appears to be multifaceted. CSF-CXCL13 is significantly
                      elevated in patients with neuroborreliosis and shows a rapid
                      and sharp decline with antibiotic therapy, but it is not
                      specific for this disease and is also highly elevated in
                      less common subacute neuroinfectious diseases, such as
                      neurosyphilis and cryptococcal meningitis or in
                      primary/secondary B-cell lymphoma.},
      keywords     = {Humans / Cross-Sectional Studies / Retrospective Studies /
                      Spinal Puncture / Multiple Sclerosis / Neurosyphilis /
                      Syndrome / Chemokine CXCL13 / CXCL13 protein, human (NLM
                      Chemicals) / CNS-inflammatory diseases (Other) / CXCL13
                      (Other) / cerebrospinal fluid (Other) / neuroborreliosis
                      (Other) / Chemokine CXCL13 (NLM Chemicals)},
      cin          = {AG Zhan},
      ddc          = {540},
      cid          = {I:(DE-2719)1910005},
      pnm          = {354 - Disease Prevention and Healthy Aging (POF4-354)},
      pid          = {G:(DE-HGF)POF4-354},
      typ          = {PUB:(DE-HGF)16},
      pmc          = {pmc:PMC10779058},
      pubmed       = {pmid:38203597},
      doi          = {10.3390/ijms25010425},
      url          = {https://pub.dzne.de/record/266804},
}