TY  - JOUR
AU  - Teipel, Stefan
AU  - Dyrba, Martin
AU  - Kleineidam, Luca
AU  - Brosseron, Frederic
AU  - Levin, Fedor
AU  - Bruno, Davide
AU  - Buerger, Katharina
AU  - Cosma, Nicoleta
AU  - Schneider, Luisa-Sophie
AU  - Düzel, Emrah
AU  - Glanz, Wenzel
AU  - Fliessbach, Klaus
AU  - Janowitz, Daniel
AU  - Kilimann, Ingo
AU  - Laske, Christoph
AU  - Munk, Matthias H
AU  - Maier, Franziska
AU  - Peters, Oliver
AU  - Pomara, Nunzio
AU  - Perneczky, Robert
AU  - Rauchmann, Boris Stephan
AU  - Priller, Josef
AU  - Ramirez, Alfredo
AU  - Roy, Nina
AU  - Schneider, Anja
AU  - Spottke, Annika
AU  - Spruth, Eike Jakob
AU  - Roeske, Sandra
AU  - Wagner, Michael
AU  - Wiltfang, Jens
AU  - Wolfsgruber, Steffen
AU  - Bartels, Claudia
AU  - Jessen, Frank
AU  - Heneka, Michael T
AU  - group, DELCODE study
TI  - Association of latent factors of neuroinflammation with Alzheimer's disease pathology and longitudinal cognitive decline.
JO  - Alzheimer's & dementia / Diagnosis, assessment & disease monitoring
VL  - 16
IS  - 1
SN  - 2352-8729
CY  - Hoboken, NJ
PB  - Wiley
M1  - DZNE-2024-00061
SP  - e12510
PY  - 2024
AB  - We investigated the association of inflammatory mechanisms with markers of Alzheimer's disease (AD) pathology and rates of cognitive decline in the AD spectrum.We studied 296 cases from the Deutsches Zentrum für Neurodegenerative Erkrankungen Longitudinal Cognitive Impairment and Dementia Study (DELCODE) cohort, and an extension cohort of 276 cases of the Alzheimer's Disease Neuroimaging Initiative study. Using Bayesian confirmatory factor analysis, we constructed latent factors for synaptic integrity, microglia, cerebrovascular endothelial function, cytokine/chemokine, and complement components of the inflammatory response using a set of inflammatory markers in cerebrospinal fluid.We found strong evidence for an association of synaptic integrity, microglia response, and cerebrovascular endothelial function with a latent factor of AD pathology and with rates of cognitive decline. We found evidence against an association of complement and cytokine/chemokine factors with AD pathology and rates of cognitive decline.Latent factors provided access to directly unobservable components of the neuroinflammatory response and their association with AD pathology and cognitive decline.
KW  - amyloid (Other)
KW  - chemokine factors (Other)
KW  - complement (Other)
KW  - endothelial function (Other)
KW  - microglia (Other)
KW  - structural equation models (Other)
KW  - tau (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:38213951
C2  - pmc:PMC10781650
DO  - DOI:10.1002/dad2.12510
UR  - https://pub.dzne.de/record/267052
ER  -