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@ARTICLE{Teipel:267052,
      author       = {Teipel, Stefan and Dyrba, Martin and Kleineidam, Luca and
                      Brosseron, Frederic and Levin, Fedor and Bruno, Davide and
                      Buerger, Katharina and Cosma, Nicoleta and Schneider,
                      Luisa-Sophie and Düzel, Emrah and Glanz, Wenzel and
                      Fliessbach, Klaus and Janowitz, Daniel and Kilimann, Ingo
                      and Laske, Christoph and Munk, Matthias H and Maier,
                      Franziska and Peters, Oliver and Pomara, Nunzio and
                      Perneczky, Robert and Rauchmann, Boris Stephan and Priller,
                      Josef and Ramirez, Alfredo and Roy, Nina and Schneider, Anja
                      and Spottke, Annika and Spruth, Eike Jakob and Roeske,
                      Sandra and Wagner, Michael and Wiltfang, Jens and
                      Wolfsgruber, Steffen and Bartels, Claudia and Jessen, Frank
                      and Heneka, Michael T and group, DELCODE study},
      collaboration = {Initiative, the Alzheimer´s Disease Neuroimaging},
      title        = {{A}ssociation of latent factors of neuroinflammation with
                      {A}lzheimer's disease pathology and longitudinal cognitive
                      decline.},
      journal      = {Alzheimer's $\&$ dementia / Diagnosis, assessment $\&$
                      disease monitoring},
      volume       = {16},
      number       = {1},
      issn         = {2352-8729},
      address      = {Hoboken, NJ},
      publisher    = {Wiley},
      reportid     = {DZNE-2024-00061},
      pages        = {e12510},
      year         = {2024},
      abstract     = {We investigated the association of inflammatory mechanisms
                      with markers of Alzheimer's disease (AD) pathology and rates
                      of cognitive decline in the AD spectrum.We studied 296 cases
                      from the Deutsches Zentrum für Neurodegenerative
                      Erkrankungen Longitudinal Cognitive Impairment and Dementia
                      Study (DELCODE) cohort, and an extension cohort of 276 cases
                      of the Alzheimer's Disease Neuroimaging Initiative study.
                      Using Bayesian confirmatory factor analysis, we constructed
                      latent factors for synaptic integrity, microglia,
                      cerebrovascular endothelial function, cytokine/chemokine,
                      and complement components of the inflammatory response using
                      a set of inflammatory markers in cerebrospinal fluid.We
                      found strong evidence for an association of synaptic
                      integrity, microglia response, and cerebrovascular
                      endothelial function with a latent factor of AD pathology
                      and with rates of cognitive decline. We found evidence
                      against an association of complement and cytokine/chemokine
                      factors with AD pathology and rates of cognitive
                      decline.Latent factors provided access to directly
                      unobservable components of the neuroinflammatory response
                      and their association with AD pathology and cognitive
                      decline.},
      keywords     = {amyloid (Other) / chemokine factors (Other) / complement
                      (Other) / endothelial function (Other) / microglia (Other) /
                      structural equation models (Other) / tau (Other)},
      cin          = {AG Heneka ; AG Heneka / AG Teipel / AG Wagner / Clinical
                      Research (Munich) / AG Düzel / Patient Studies Bonn / AG
                      Gasser / AG Peters / AG Priller / AG Simons / AG Dichgans /
                      AG Spottke / AG Schneider / AG Wiltfang / AG Jessen},
      ddc          = {610},
      cid          = {I:(DE-2719)1011303 / I:(DE-2719)1510100 /
                      I:(DE-2719)1011201 / I:(DE-2719)1111015 / I:(DE-2719)5000006
                      / I:(DE-2719)1011101 / I:(DE-2719)1210000 /
                      I:(DE-2719)5000000 / I:(DE-2719)5000007 / I:(DE-2719)1110008
                      / I:(DE-2719)5000022 / I:(DE-2719)1011103 /
                      I:(DE-2719)1011305 / I:(DE-2719)1410006 /
                      I:(DE-2719)1011102},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      experiment   = {EXP:(DE-2719)DELCODE-20140101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38213951},
      pmc          = {pmc:PMC10781650},
      doi          = {10.1002/dad2.12510},
      url          = {https://pub.dzne.de/record/267052},
}